Juxtacortical Paramagnetic Rim A New MRI Marker to Characterize Focal Cortical Pathology in Multiple Sclerosis?

被引：0

作者：

Rocca, Maria A. ^{[1
,2
,3
]}

Preziosa, Paolo ^{[1
,2
,3
]}

Filippi, Massimo ^{[1
,2
,3
,4
,5
]}

机构：

[1] IRCCS San Raffaele Sci Inst, Neuroimaging Res Unit, Milan, Italy

[2] IRCCS San Raffaele Sci Inst, Div Neurosci, Neurol Unit, Milan, Italy

[3] Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Milan, Italy

[4] IRCCS San Raffaele Sci Inst, Neurorehabil Unit, Milan, Italy

[5] IRCCS San Raffaele Sci Inst, Neurophysiol Serv, Milan, Italy

来源：

NEUROLOGY | 2024年 / 102卷 / 03期

关键词：

LESIONS; HETEROGENEITY;

D O I：

10.1212/WNL.0000000000208085

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The accumulation of focal white matter and cortical inflammatory demyelinating lesions represents the pathologic hallmark of multiple sclerosis (MS).(1) Typically, acute white matter lesions are characterized by an increased blood-brain barrier (BBB) permeability, an inflammatory infiltrate, and ongoing demyelination and axonal transection.(2) In the chronic phase, a substantial proportion of white matter lesions, known as chronic active lesions, exhibit a hypocellular core with a rim of iron-laden activated microglia/macrophages, with no abnormal BBB permeability.(2) Some of these lesions can be identified on susceptibility-based MRI as exhibiting a paramagnetic rim, and they are, therefore, referred to as "paramagnetic rim lesions" (PRLs).(3)

引用

页数：3

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