The gut, a whistleblower, in the early stages of Parkinson's disease

被引：0

作者：

Hazart, Doriane ^{[1
]}

Rolli-Derkinderen, Malvyne ^{[2
]}

Delhomme, Brigitte ^{[1
]}

Derkinderen, Pascal ^{[3
]}

Oheim, Martin ^{[1
]}

Ricard, Clement ^{[1
]}

机构：

[1] Univ Paris Cite, SPPIN St Peres Paris Inst Neurosci, CNRS, UMR 8003, Paris, France

[2] Nantes Univ, Inserm U1235, TENSGBD The Enter Nervous Syst Gut & Brain Disorde, Nantes, France

[3] Nantes Univ, CHU Nantes, TENSGBD The Enter Nervous Syst Gut & Brain Disorde, Nantes, France

来源：

M S-MEDECINE SCIENCES | 2024年 / 40卷 / 6-7期

关键词：

BRAIN; FLUORESCENCE; CONSTIPATION;

D O I：

10.1051/medsci/2024082

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The enteric nervous system (ENS), often called the "second brain", plays a crucial role in regulating digestive functions. Dysfunctions of the ENS are associated with several diseases such as Parkinson's disease. Recent studies suggest that early digestive disorders, notably chronic constipation, may be early signs of this neurodegenerative disease. Three-dimensional imaging of the ENS offers new insights into early diagnosis, in particular through the analysis of intestinal biopsies. This new research axis raises questions about the intestinal cause of Parkinson's disease, and opens the door to a better understanding and earlier treatment of this disease.

引用

页码：544 / 549

页数：6

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