The COVID-19 pandemic affected millions of people worldwide, and the hemodialysis population was one of the most affected. Anxiety, defined as an affective state characterized by psychomotor restlessness, indistinct fear, and no discernible object, is growing worldwide and among hemodialysis patients, as well. The pandemic has extensively worsened social and economic challenges and has further expanded existing psychosocial alterations in this patient category. With a heightened awareness of their susceptibility to contracting COVID-19 and experiencing severe complications, coupled with concerns about financial instability and the loss of loved ones, the imposition of quarantine and isolation measures has intensified levels of anxiety, depression, and sleep disturbances among these patients. Materials and methods: In the current study, all 102 patients included were enrolled in the chronic hemodialysis program at AVITUM-BBRAUN Suceava. All patients included in the analysis completed the Kidney Disease and Quality of Life (KDQOLTM-36)-36) questionnaire. Results: The findings revealed an increase in anxiety, perception of pain, and sleep disturbances, contributing to an overall low quality of life Score among the participants. Conclusions: Chronic kidney disease profoundly impacts the daily lives of HD-patients, affecting not only physical health but also emotional well-being and quality of life. COVID-19 pandemic had an additional negative impact. Providing adequate support and care to patients with chronic kidney disease is crucial for effectively managing the condition and improving their quality of life and adherence to treatment.