RNAi mediated inhibition of beta-catenin demonstrates anti-tumor efficacy and immune microenvironment modulation in preclinical hepatocellular carcinoma models

被引：0
|
作者：
Dadali, Tulin
Miller, Spencer
Saawant, Gaurav
Abbott, Stephen
Yu, Mikyung
Morskaya, Svetlana
Lehrich, Brandon
Monga, Satdarshan
Lau, Gloria
Maier, Martin
Broom, Wendy
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-5924
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
5924
引用
收藏
页数：2
相关论文
共 50 条
  • [1] EFFICACY OF RNAi-MEDIATED BETA-CATENIN INHIBITION IN MULTIPLE IMMUNOCOMPETENT MOUSE MODELS OF HEPATOCELLULAR CARCINOMA
    Lehrich, Brandon M.
    Tao, Junyan
    Liu, Silvia
    Delgado, Evan
    Varma, Anya Singh
    Liu, Yuqing
    Poddar, Minakshi
    Singh, Sucha
    Dadali-Abel, Tulin
    Broom, Wendy
    Bell, Aaron W.
    Monga, Satdarshan
    HEPATOLOGY, 2023, 78 : S1935 - S1936
  • [2] Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma
    Hung Huynh
    Richard Ong
    Khee Chee Soo
    Angiogenesis, 2012, 15 : 59 - 70
  • [3] Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma
    Huynh, Hung
    Ong, Richard
    Soo, Khee Chee
    ANGIOGENESIS, 2012, 15 (01) : 59 - 70
  • [4] Efficacy of RNAi-mediated β-catenin Inhibition in Preclinical Mouse Models of Hepatoblastoma
    Lehrich, Brandon M.
    Tao, Junyan
    Hurley, Edward
    Cao, Catherine
    Liu, Yuqing
    Poddar, Minakshi
    Singh, Sucha
    Dadali-Abel, Tulin
    Broom, Wendy
    Monga, Satdarshan P.
    AMERICAN JOURNAL OF PATHOLOGY, 2024, 194 (04): : S19 - S19
  • [5] SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
    Wang, Zengbin
    Pan, Banglun
    Su, Lili
    Yu, Huahui
    Wu, Xiaoxuan
    Yao, Yuxin
    Zhang, Xiaoxia
    Qiu, Jiacheng
    Tang, Nanhong
    CELLULAR ONCOLOGY, 2024, 47 (02) : 513 - 532
  • [6] SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
    Zengbin Wang
    Banglun Pan
    Lili Su
    Huahui Yu
    Xiaoxuan Wu
    Yuxin Yao
    Xiaoxia Zhang
    Jiacheng Qiu
    Nanhong Tang
    Cellular Oncology, 2024, 47 : 513 - 532
  • [7] Anti-tumor efficacy and safety of AEV01 in preclinical glioblastoma and hepatocellular carcinoma models
    Biswas, Indrani
    Precilla, Senthilathiban Daisy
    Kumar, Aravinda
    Sekhar, M. M.
    Medasani, Renu
    Anitha, T. S.
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [8] Condensate modulator sequesters beta-catenin into depot condensates and demonstrates competitive anti-tumor activity in animal models ofcolorectal cancer
    Salojin, Costa
    Baumann, Douglas
    Talbot, Adam
    West, Kip
    Durand-Reville, Thomas
    Klein, Isaac
    Boija, Ann
    CANCER RESEARCH, 2024, 84 (07)
  • [9] BETA-CATENIN INFLUENCES B CELL RECRUITMENT TO THE TUMOR MICROENVIRONMENT IN BETA-CATENIN-MUTATED HEPATOCELLULAR CARCINOMA CONTRIBUTING TO PATIENT SURVIVAL
    Lehrich, Brandon M.
    Tao, Junyan
    Delgado, Evan
    Singhi, Aatur
    Liu, Silvia
    Monga, Satdarshan
    HEPATOLOGY, 2023, 78 : S1931 - S1932
  • [10] RNAi-based β-catenin inhibition in combination with MEK inhibition promotes synergistic anti-tumor efficacy and overcomes resistance with MEK inhibition promotes synergistic anti-tumor efficacy and overcomes resistance
    Ganesh, Shanthi
    Shui, Serena
    Chopda, Girish
    Koser, Martin
    Craig, Kevin
    Dutta, Chaitali
    Lai, Cheng
    Dudek, Hank
    Wang, Weimin
    Brown, Bob D.
    Abrams, Marc
    CANCER RESEARCH, 2017, 77
12345