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- [1] CELLULAR SENESCENCE IMPLICATED IN SEPSIS-INDUCED MUSCLE WEAKNESS AND AMELIORATED WITH METFORMINSHOCK, 2023, 59 (04): : 646 - 656Chen, Juan论文数: 0 引用数: 0 h-index: 0机构: Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R China Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R ChinaChen, Xin Yi论文数: 0 引用数: 0 h-index: 0机构: Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R China Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R ChinaCong, Xiao Xia论文数: 0 引用数: 0 h-index: 0机构: Zhejiang Univ, Sch Med, Dept Biochem, Hangzhou 310058, Peoples R China Zhejiang Univ, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cell & Regen, Key Lab Tissue Engn & Regenerat Med Zhejiang Prov, Sch Med, Hanghzhou, Peoples R China Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R ChinaWang, Shen论文数: 0 引用数: 0 h-index: 0机构: Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R China Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R ChinaXu, Shui Bo论文数: 0 引用数: 0 h-index: 0机构: Zhejiang Univ, Sch Med, Dept Biochem, Hangzhou 310058, Peoples R China Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R ChinaSun, Yu Ting论文数: 0 引用数: 0 h-index: 0机构: Zhejiang Univ, Sch Med, Dept Biochem, Hangzhou 310058, Peoples R China Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R ChinaZhou, Yi Ting论文数: 0 引用数: 0 h-index: 0机构: Zhejiang Univ, Sch Med, Dept Biochem, Hangzhou 310058, Peoples R China Zhejiang Univ, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cell & Regen, Key Lab Tissue Engn & Regenerat Med Zhejiang Prov, Sch Med, Hanghzhou, Peoples R China Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R ChinaZheng, Li Ling论文数: 0 引用数: 0 h-index: 0机构: Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R China Zhejiang Univ, Sch Med, Dept Biochem, Hangzhou 310058, Peoples R China Zhejiang Univ, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cell & Regen, Key Lab Tissue Engn & Regenerat Med Zhejiang Prov, Sch Med, Hanghzhou, Peoples R China Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R ChinaHuang, Man论文数: 0 引用数: 0 h-index: 0机构: Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R China Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gen Intens Care Unit, Hangzhou 310058, Peoples R China
- [2] Exploring the Muscle Metabolomics in the Mouse Model of Sepsis-Induced Acquired WeaknessEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022Jiang, Yikang论文数: 0 引用数: 0 h-index: 0机构: Chongqing Med Univ, Dept Clin Coll 1, Chongqing, Peoples R China Chongqing Med Univ, Dept Clin Coll 1, Chongqing, Peoples R ChinaWei, Qiang论文数: 0 引用数: 0 h-index: 0机构: Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, Chongqing, Peoples R China Chongqing Med Univ, Dept Clin Coll 1, Chongqing, Peoples R ChinaLiu, Wei论文数: 0 引用数: 0 h-index: 0机构: Chongqing Med Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Chongqing, Peoples R China Chongqing Med Univ, Dept Clin Coll 1, Chongqing, Peoples R ChinaChen, Qiunan论文数: 0 引用数: 0 h-index: 0机构: Chongqing Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Chongqing, Peoples R China Chongqing Med Univ, Dept Clin Coll 1, Chongqing, Peoples R ChinaChen, Xia论文数: 0 引用数: 0 h-index: 0机构: Army Med Ctr PLA, Dept Hlth Management, Chongqing, Peoples R China Chongqing Med Univ, Dept Clin Coll 1, Chongqing, Peoples R ChinaYuan, Zhongzhen论文数: 0 引用数: 0 h-index: 0机构: Chongqing Univ Canc Hosp, Chongqing Canc Hosp, Chongqing Canc Inst, Dept Pharm, Chongqing, Peoples R China Chongqing Med Univ, Dept Clin Coll 1, Chongqing, Peoples R ChinaLuo, Na论文数: 0 引用数: 0 h-index: 0机构: Chongqing Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Chongqing, Peoples R China Chongqing Med Univ, Dept Clin Coll 1, Chongqing, Peoples R ChinaChen, Xi论文数: 0 引用数: 0 h-index: 0机构: Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, Chongqing, Peoples R China Chongqing Med Univ, Dept Clin Coll 1, Chongqing, Peoples R ChinaWang, Chuanjiang论文数: 0 引用数: 0 h-index: 0机构: Chongqing Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Chongqing, Peoples R China Chongqing Med Univ, Dept Clin Coll 1, Chongqing, Peoples R China
- [3] The Gut Microbiome Regulates Sepsis-Induced Skeletal Muscle AtrophyAMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 207Bongers, K. S.论文数: 0 引用数: 0 h-index: 0机构: Univ Michigan, Pulm & Crit Care Med, Ann Arbor, MI USA Univ Michigan, Pulm & Crit Care Med, Ann Arbor, MI USA论文数: 引用数: h-index:机构:Winner, K. M.论文数: 0 引用数: 0 h-index: 0机构: Univ Michigan, Internal Med, Ann Arbor, MI USA Univ Michigan, Pulm & Crit Care Med, Ann Arbor, MI USAMcDonald, R. A.论文数: 0 引用数: 0 h-index: 0机构: Univ Michigan, Pulm & Crit Care Med, Ann Arbor, MI USA Univ Michigan, Pulm & Crit Care Med, Ann Arbor, MI USAFalkowski, N. R.论文数: 0 引用数: 0 h-index: 0机构: Univ Michigan, Pulm & Crit Care Med, Ann Arbor, MI USA Univ Michigan, Pulm & Crit Care Med, Ann Arbor, MI USADickson, R. P.论文数: 0 引用数: 0 h-index: 0机构: Univ Michigan, Internal Med, Pulm & Crit Care Med, Ann Arbor, MI USA Univ Michigan, Pulm & Crit Care Med, Ann Arbor, MI USA
- [4] Skeletal Muscle and Lymphocyte Mitochondrial Dysfunctions in Septic Shock Trigger ICU-Acquired Weakness and Sepsis-Induced ImmunoparalysisBIOMED RESEARCH INTERNATIONAL, 2017, 2017Maestraggi, Quentin论文数: 0 引用数: 0 h-index: 0机构: Hop Univ Strasbourg, Hop Hautepierre, Serv Reanimat Med, Ave Moliere, F-67098 Strasbourg, France Univ Strasbourg, FMTS, Fac Med, Inst Physiol,Equipe Accueil 3072 Mitochondrie Str, 11 Rue Human, F-67000 Strasbourg, France Hop Univ Strasbourg, Hop Hautepierre, Serv Reanimat Med, Ave Moliere, F-67098 Strasbourg, FranceLebas, Benjamin论文数: 0 引用数: 0 h-index: 0机构: Univ Strasbourg, FMTS, Fac Med, Inst Physiol,Equipe Accueil 3072 Mitochondrie Str, 11 Rue Human, F-67000 Strasbourg, France Hop Univ Strasbourg, Hop Hautepierre, Serv Anesthesie Reanimat Chirurg, Ave Moliere, F-67098 Strasbourg, France Hop Univ Strasbourg, Hop Hautepierre, Serv Reanimat Med, Ave Moliere, F-67098 Strasbourg, FranceClere-Jehl, Raphael论文数: 0 引用数: 0 h-index: 0机构: Hop Univ Strasbourg, Hop Hautepierre, Serv Reanimat Med, Ave Moliere, F-67098 Strasbourg, France Univ Strasbourg, FMTS, Fac Med, Inst Physiol,Equipe Accueil 3072 Mitochondrie Str, 11 Rue Human, F-67000 Strasbourg, France Hop Univ Strasbourg, Hop Hautepierre, Serv Reanimat Med, Ave Moliere, F-67098 Strasbourg, FranceLudes, Pierre-Olivier论文数: 0 引用数: 0 h-index: 0机构: Univ Strasbourg, FMTS, Fac Med, Inst Physiol,Equipe Accueil 3072 Mitochondrie Str, 11 Rue Human, F-67000 Strasbourg, France Hop Univ Strasbourg, Hop Hautepierre, Serv Anesthesie Reanimat Chirurg, Ave Moliere, F-67098 Strasbourg, France Hop Univ Strasbourg, Hop Hautepierre, Serv Reanimat Med, Ave Moliere, F-67098 Strasbourg, FranceThien-Nga Chamaraux-Tran论文数: 0 引用数: 0 h-index: 0机构: Univ Strasbourg, FMTS, Fac Med, Inst Physiol,Equipe Accueil 3072 Mitochondrie Str, 11 Rue Human, F-67000 Strasbourg, France Hop Univ Strasbourg, Hop Hautepierre, Serv Anesthesie Reanimat Chirurg, Ave Moliere, F-67098 Strasbourg, France Univ Strasbourg, INSERM U964, CNRS UMR7104, IGBMC, Illkirch Graffenstaden, France Hop Univ Strasbourg, Hop Hautepierre, Serv Reanimat Med, Ave Moliere, F-67098 Strasbourg, France论文数: 引用数: h-index:机构:Diemunsch, Pierre论文数: 0 引用数: 0 h-index: 0机构: Univ Strasbourg, FMTS, Fac Med, Inst Physiol,Equipe Accueil 3072 Mitochondrie Str, 11 Rue Human, F-67000 Strasbourg, France Hop Univ Strasbourg, Hop Hautepierre, Serv Anesthesie Reanimat Chirurg, Ave Moliere, F-67098 Strasbourg, France Hop Univ Strasbourg, Hop Hautepierre, Serv Reanimat Med, Ave Moliere, F-67098 Strasbourg, FranceGeny, Bernard论文数: 0 引用数: 0 h-index: 0机构: Univ Strasbourg, FMTS, Fac Med, Inst Physiol,Equipe Accueil 3072 Mitochondrie Str, 11 Rue Human, F-67000 Strasbourg, France Hop Univ Strasbourg, Nouvel Hop Civil, Serv Physiol & Explorat Fonct, 1 Pl Hop, F-67091 Strasbourg, France Hop Univ Strasbourg, Hop Hautepierre, Serv Reanimat Med, Ave Moliere, F-67098 Strasbourg, France论文数: 引用数: h-index:机构:
- [5] SEPSIS-INDUCED MYOFIBRILLAR PROTEIN CATABOLISM IN RAT SKELETAL-MUSCLELIFE SCIENCES, 1994, 55 (18) : 1383 - 1391AHMAD, S论文数: 0 引用数: 0 h-index: 0机构: LOYOLA UNIV,MED CTR,DEPT PHYSIOL,MAYWOOD,IL 60153KARLSTAD, MD论文数: 0 引用数: 0 h-index: 0机构: LOYOLA UNIV,MED CTR,DEPT PHYSIOL,MAYWOOD,IL 60153CHOUDHRY, MA论文数: 0 引用数: 0 h-index: 0机构: LOYOLA UNIV,MED CTR,DEPT PHYSIOL,MAYWOOD,IL 60153SAYEED, MM论文数: 0 引用数: 0 h-index: 0机构: LOYOLA UNIV,MED CTR,DEPT PHYSIOL,MAYWOOD,IL 60153
- [6] EDRF AS A POSSIBLE MEDIATOR OF SEPSIS-INDUCED ARTERIOLAR DILATION IN SKELETAL-MUSCLEAMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (03): : H880 - H887LUBBE, AS论文数: 0 引用数: 0 h-index: 0机构: FREE UNIV BERLIN, R VIRCHOW MED SCH,DEPT MED ONCOL, W-1000 BERLIN 19, GERMANYGARRISON, RN论文数: 0 引用数: 0 h-index: 0机构: FREE UNIV BERLIN, R VIRCHOW MED SCH,DEPT MED ONCOL, W-1000 BERLIN 19, GERMANYCRYER, HM论文数: 0 引用数: 0 h-index: 0机构: FREE UNIV BERLIN, R VIRCHOW MED SCH,DEPT MED ONCOL, W-1000 BERLIN 19, GERMANYALSIP, NL论文数: 0 引用数: 0 h-index: 0机构: FREE UNIV BERLIN, R VIRCHOW MED SCH,DEPT MED ONCOL, W-1000 BERLIN 19, GERMANYHARRIS, PD论文数: 0 引用数: 0 h-index: 0机构: FREE UNIV BERLIN, R VIRCHOW MED SCH,DEPT MED ONCOL, W-1000 BERLIN 19, GERMANY
- [7] Role of IL-15 in Sepsis-Induced Skeletal Muscle Atrophy and ProteolysisTUBERCULOSIS AND RESPIRATORY DISEASES, 2012, 73 (06) : 312 - 319论文数: 引用数: h-index:机构:Cho, Hee-Young论文数: 0 引用数: 0 h-index: 0机构: Gyeongsang Natl Univ Hosp, Biomed Res Inst, Jinju, South Korea Gyeongsang Natl Univ, Sch Med, Inst Hlth Sci, Dept Internal Med, 92 Chiram Dong, Jinju 660751, South Korea论文数: 引用数: h-index:机构:
- [8] Protective Effects of Glutamine and Leucine Supplementation on Sepsis-Induced Skeletal Muscle InjuriesINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (23)Hou, Yu-Chen论文数: 0 引用数: 0 h-index: 0机构: Taipei Med Univ, Coll Nutr, Master Program Food Safety, Taipei 11031, Taiwan Taipei Med Univ, Sch Food Safety, Coll Nutr, Taipei 11031, Taiwan Taipei Med Univ Hosp, Nutr Res Ctr, Taipei 11031, Taiwan Taipei Med Univ, Coll Nutr, Master Program Food Safety, Taipei 11031, TaiwanPai, Man-Hui论文数: 0 引用数: 0 h-index: 0机构: Taipei Med Univ, Sch Med, Dept Anat & Cell Biol, Coll Med, Taipei 11031, Taiwan Taipei Med Univ, Coll Nutr, Master Program Food Safety, Taipei 11031, TaiwanWu, Jin-Ming论文数: 0 引用数: 0 h-index: 0机构: Natl Taiwan Univ, Natl Taiwan Univ Hosp & Coll Med, Dept Surg, Taipei 11031, Taiwan Natl Taiwan Univ Hosp, Hsin Chu Branch, Dept Surg, Hsinchu 302, Hsinchu County, Taiwan Taipei Med Univ, Coll Nutr, Master Program Food Safety, Taipei 11031, TaiwanYang, Po-Jen论文数: 0 引用数: 0 h-index: 0机构: Natl Taiwan Univ, Natl Taiwan Univ Hosp & Coll Med, Dept Surg, Taipei 11031, Taiwan Taipei Med Univ, Coll Nutr, Master Program Food Safety, Taipei 11031, TaiwanLee, Po-Chu论文数: 0 引用数: 0 h-index: 0机构: Natl Taiwan Univ, Natl Taiwan Univ Hosp & Coll Med, Dept Surg, Taipei 11031, Taiwan Taipei Med Univ, Coll Nutr, Master Program Food Safety, Taipei 11031, TaiwanChen, Kuen-Yuan论文数: 0 引用数: 0 h-index: 0机构: Natl Taiwan Univ, Natl Taiwan Univ Hosp & Coll Med, Dept Surg, Taipei 11031, Taiwan Taipei Med Univ, Coll Nutr, Master Program Food Safety, Taipei 11031, TaiwanYeh, Sung-Ling论文数: 0 引用数: 0 h-index: 0机构: Natl Taiwan Univ, Natl Taiwan Univ Hosp & Coll Med, Dept Surg, Taipei 11031, Taiwan Taipei Med Univ, Coll Nutr, Master Program Food Safety, Taipei 11031, TaiwanLin, Ming-Tsan论文数: 0 引用数: 0 h-index: 0机构: Natl Taiwan Univ, Natl Taiwan Univ Hosp & Coll Med, Dept Surg, Taipei 11031, Taiwan Taipei Med Univ, Coll Nutr, Master Program Food Safety, Taipei 11031, Taiwan
- [9] Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketonesCRITICAL CARE, 2019, 23 (1)Goossens, Chloe论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Lab Intens Care Med, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, BelgiumWeckx, Ruben论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Lab Intens Care Med, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, BelgiumDerde, Sarah论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Lab Intens Care Med, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, BelgiumDufour, Thomas论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Lab Intens Care Med, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, BelgiumVander Perre, Sarah论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Lab Intens Care Med, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, BelgiumPauwels, Lies论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Lab Intens Care Med, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, BelgiumThiessen, Steven E.论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Lab Intens Care Med, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, BelgiumVan Veldhoven, Paul P.论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Lab Lipid Biochem & Prot Interact, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, BelgiumVan den Berghe, Greet论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Lab Intens Care Med, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, BelgiumLangouche, Lies论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Lab Intens Care Med, Dept Cellular & Mol Med, B-3000 Leuven, Belgium Katholieke Univ Leuven, Clin Div, Dept Cellular & Mol Med, B-3000 Leuven, Belgium
- [10] Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketonesCritical Care, 23Chloë Goossens论文数: 0 引用数: 0 h-index: 0机构: KU Leuven,Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular MedicineRuben Weckx论文数: 0 引用数: 0 h-index: 0机构: KU Leuven,Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular MedicineSarah Derde论文数: 0 引用数: 0 h-index: 0机构: KU Leuven,Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular MedicineThomas Dufour论文数: 0 引用数: 0 h-index: 0机构: KU Leuven,Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular MedicineSarah Vander Perre论文数: 0 引用数: 0 h-index: 0机构: KU Leuven,Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular MedicineLies Pauwels论文数: 0 引用数: 0 h-index: 0机构: KU Leuven,Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular MedicineSteven E. Thiessen论文数: 0 引用数: 0 h-index: 0机构: KU Leuven,Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular MedicinePaul P. Van Veldhoven论文数: 0 引用数: 0 h-index: 0机构: KU Leuven,Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular MedicineGreet Van den Berghe论文数: 0 引用数: 0 h-index: 0机构: KU Leuven,Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular MedicineLies Langouche论文数: 0 引用数: 0 h-index: 0机构: KU Leuven,Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine