Association of TG/HDL Ratio with Cardiovascular Mortality in Patients Who are on Hemodialysis

Objective: There is a relation between triglyceride/high-density lipoprotein (TG/HDL) ratio, and cardiovascular and all-cause mortality. No study has been conducted on this relationship in cases with end-stage renal disease who are on hemodialysis in Turkey. Therefore, we aimed to see the relation between TG/HDL ratio and cardiovascular mortality in hemodialysis patients. Methods: This study included 344 cases who were aged >= 18 years and on hemodialysis. These cases were divided into two groups as cardiovascular death (n=31) and survivors (n=313). Primary endpoint of this study was cardiovascular mortality. Results: Among 344 patients, 74.1% were males, and the mean age was 43.7 +/- 12.6 years. Dialysis duration was 1.1 (3.1) years, and the total follow-up duration was 5.9 (2.9) years. TG/HDL ratio was similar in both groups (p>0.05). Age [human resource (HR): 1.02, 95% confidence interval (CI): (1,055-1.09), p=0.02], HbA1c [HR: 1,292, 95% CI: (1,080-1,546), p=0.05], and TG/HDL ratio [HR: 1,078, 95% CI: (1,009-1.51), p=0.026] were independent predictors of cardiovascular mortality. Kaplan-Meier curves revealed that cardiovascular mortality was higher in the group using fenofibrate [p (log-rank) =0.01]. Conclusion: TG/HDL ratio is an inexpensive, simply applicable tool that may predict cardiovascular mortality in hemodialysis patients. Therefore, it may significantly benefit in optimizing cardiovascular risk management and treatment goals in these patients.