Advancements in Early Detection and Screening Strategies for Pancreatic Cancer: From Genetic Susceptibility to Novel Biomarkers

被引:1
|
作者
Shah, Yash [1 ]
Dahiya, Dushyant Singh [2 ]
Tiwari, Angad [3 ]
Kumar, Harendra [4 ]
Gangwani, Manesh Kumar [5 ]
Ali, Hassam [6 ]
Hayat, Umar [7 ]
Alsakarneh, Saqr [8 ]
Singh, Sahib [9 ]
Malik, Sheza [10 ]
Sohail, Amir H. [11 ]
Chandan, Saurabh [12 ]
Ali, Meer A. [5 ]
Inamdar, Sumant [5 ]
机构
[1] Wayne State Univ, Dept Internal Med, Trinity Hlth Oakland, Pontiac, MI 48341 USA
[2] Univ Kansas, Sch Med, Div Gastroenterol Hepatol & Motil, Kansas City, KS 66160 USA
[3] Maharani Laxmi Bai Med Coll, Dept Internal Med, Jhansi 284001, Uttar Pradesh, India
[4] Dow Univ Hlth Sci, Dept Internal Med, Karachi 74200, Pakistan
[5] Univ Arkansas Med Sci, Dept Gastroenterol & Hepatol, Little Rock, AR 72205 USA
[6] East Carolina Univ, Brody Sch Med, Div Gastroenterol Hepatol & Nutr, Greenville, NC 27834 USA
[7] Geisinger Wyoming Valley Med Ctr, Dept Internal Med, Wilkes Barre, PA 18711 USA
[8] Univ Missouri Kansas City, Dept Internal Med, Kansas City, MO 64110 USA
[9] Sinai Hosp, Dept Internal Med, Baltimore, MD 21215 USA
[10] Rochester Gen Hosp, Dept Internal Med, Rochester, NY 14621 USA
[11] Univ New Mexico, Dept Surg, Albuquerque, NM 87131 USA
[12] Advent Hlth, Ctr Intervent Endoscopy CIE, Orlando, FL 32803 USA
关键词
pancreatic cancer; screening; high risk; hereditary; HIGH-RISK INDIVIDUALS; PEUTZ-JEGHERS-SYNDROME; FAMILIAL ADENOMATOUS POLYPOSIS; ENDOSCOPIC ULTRASOUND; HEREDITARY PANCREATITIS; ATAXIA-TELANGIECTASIA; DIAGNOSTIC-ACCURACY; BREAST-CANCER; FOLLOW-UP; TUMOR;
D O I
10.3390/jcm13164706
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pancreatic cancer is a rare but lethal cancer due to its biologically aggressive nature, advanced stage at the time of diagnosis, and poor response to oncologic therapies. The risk of pancreatic cancer is significantly higher to 5% in certain high-risk individuals with inherited genetic susceptibility. Screening for pancreatic cancer in these individuals from high-risk groups can help with the early detection of pancreatic cancer as well as the detection of precursor lesions leading to early surgical resection and improved overall outcomes. The advancements in radiological imaging as well as advanced endoscopic procedures has made a significant impact on the early diagnosis, surveillance, and staging of pancreatic cancer. There is also a significant advancement in the development of biomarkers for the early detection of pancreatic cancer, which has also led to the development of liquid biopsy, allowing for microRNA detection in serum and circulating tumor cells. Various societies and organizations have provided guidelines for pancreatic cancer screening and surveillance in high-risk individuals. In this review, we aim to discuss the hereditary risk factors for developing pancreatic cancer, summarize the screening recommendations by different societies, and discuss the development of novel biomarkers and areas for future research in pancreatic cancer screening for high-risk individuals.
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页数:21
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