Prognostic Role of Pre- and Post-Treatment [18F]FDG PET/CT in Squamous Cell Carcinoma of the Oropharynx in Patients Treated with Chemotherapy and Radiotherapy

被引：0
|
作者：
Dondi, Francesco [1 ,2 ]
Gazzilli, Maria [3 ]
Albano, Domenico [1 ,2 ]
Rizzo, Alessio [4 ]
Treglia, Giorgio [5 ,6 ,7 ]
Pisani, Antonio Rosario [8 ]
Palumbo, Carmen [8 ]
Rubini, Dino [9 ]
Racca, Manuela [4 ]
Rubini, Giuseppe [8 ]
Bertagna, Francesco [1 ,2 ]
机构：
[1] Univ Brescia, Nucl Med, I-25123 Brescia, Italy
[2] ASST Spedali Civili Brescia, I-25123 Brescia, Italy
[3] ASL Bari PO Venere, Nucl Med, I-70012 Bari, Italy
[4] IRCCS, Candiolo Canc Inst, Dept Nucl Med, FPO, I-10060 Turin, Italy
[5] Ente Osped Cantonale, Imaging Inst Southern Switzerland, Clin Nucl Med, CH-6501 Bellinzona, Switzerland
[6] Univ Lausanne, Fac Biol & Med, CH-1011 Lausanne, Switzerland
[7] Univ Svizzera Italiana, Fac Biomed Sci, CH-6900 Lugano, Switzerland
[8] Univ Bari Aldo Moro, Interdisciplinary Dept Med, Nucl Med Sect, I-70124 Bari, Italy
[9] Univ Campania L Vanvitelli, Dept Precis Med, I-80138 Naples, Italy
来源：
MEDICAL SCIENCES | 2024年 / 12卷 / 03期
关键词：
18]F-FDG; positron emission tomography; PET/CT; oropharynx; head and neck; squamous cell carcinoma; SCC; HPV; DISTANT METASTASES; F-18-FDG PET; NECK-CANCER; BASE-LINE; HEAD; IMPACT; PHARYNX;
D O I：
10.3390/medsci12030036
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: The prognostic role of imaging with [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in oropharynx cancer (OPC) has been demonstrated in the past. The aim of this study was to assess the prognostic impact of both baseline and post-treatment PET/CT in patients with OPC and treated with chemo- and/or radiotherapy. Methods: The PET/CT parameters of scans performed before and after therapy were collected and analyzed to find significant prognosticators for progression-free survival (PFS) and overall survival (OS). Human papillomavirus (HPV) infection's influence on the prognosis was also taken into account. Results: A total of 66 patients were included in the study. The staging volumetric parameters of PET/CT were significant prognosticators for OS, while the same parameters were affordable predictors for PFS at the restaging evaluation. No significant correlations between HPV infection and PET/CT parameters were reported. Conclusion: The prognostic role of volumetric [18F]FDG PET/CT parameters in patients with OPC was reported.
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页数：13
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