Enhanced Stable and Efficient of Dual-Ligand Zirconium-Based Metal-Organic Frameworks for Synergistic Photodynamic Inactivation

Porphyrins, known for generating toxic singlet oxygen (1O2) to combat bacteria, face challenges such as hydrophilicity and limited lifespan and 1O2 yield. Conversely, triterpenoid compounds like ammonium glycyrrhizinate (AG) offer antioxidative and antibacterial properties but lack efficacy and stability. Combining them in Metal-Organic Frameworks (MOFs) yields dual-ligand zirconium (Zr)-basedMOFs (M-TG), capitalizing on porphyrins' membrane-disrupting ability and AG's inhibition of bacterial membrane synthesis for a synergistic antibacterial effect. M-TG resolves activity loss, enhances reactive oxygen species (ROS) yield, and extends stability, achieving a remarkable 99.999% sterilization rate. This innovative approach maximizes ligand properties through synergistic effects, promising significant advancements in antibacterial material design. Enhancing the antimicrobial properties of Metal-Organic Framework and imparting antioxidant properties through the strategy of "leveraging strengths and compensating weaknesses", which maximizes the potential of ammonium glycyrrhiza to improve the sterilization capacity of porphyrins in light and low oxygen environments. This strategy helps the development of integrated functional materials and offers nanoplatform for bacteriostatic preservation. image