Design, Synthesis, Anticholinesterase and Antidiabetic Inhibitory Activities, and Molecular Docking of Novel Fluorinated Sulfonyl Hydrazones

In this study, it was aimed to synthesize (E)-N '-(2-hydroxybenzylidene)-substituted benzenesulfonohydrazide (<bold>1</bold>-<bold>7</bold>) from the 2-hydroxybenzaldehyde reaction of different substituted fluorinated sulfonyl hydrazides. The structures of the synthesized molecules were characterized by elemental analysis, FTIR, H-1 NMR, C-13 NMR, F-19 NMR, and 2D NMR (HMBC, correlation spectroscopy, and HQSC). The anticholinesterase (AChE and BChE) and antidiabetic (alpha-glucosidase, alpha-amylase) inhibition activities of the synthesized compounds were evaluated. According to biological activity test results, (E)-N '-(2-hydroxybenzylidene)-4-(trifluoromethoxy)benzenesulfonohydrazide (compound <bold>7</bold> among hydrazone derivatives <bold>1</bold>-<bold>7</bold>) demonstrated better BChE inhibitor activity than galantamine in anticholinesterase inhibition; and in the alpha-glucosidase and alpha-amylase assay, it exhibited more antidiabetic inhibition activity than the reference standard.