Surface Engineering of Magnetic Iron Oxide Nanoparticles for Breast Cancer Diagnostics and Drug Delivery

被引：3

作者：

Xie, Mengjie ^{[1
]}

Meng, Fansu ^{[2
]}

Wang, Panpan ^{[3
]}

Diaz-Garcia, Alicia Marcelina ^{[4
]}

Parkhats, Marina ^{[5
]}

Santos-Oliveira, Ralph ^{[6
]}

Asim, Mulazim Hussain ^{[7
]}

Bostan, Nazish ^{[8
]}

Gu, Honghui ^{[9
]}

Yang, Lina ^{[9
]}

Li, Qi ^{[9
]}

Yang, Zhenjiang ^{[9
]}

Lai, Haibiao ^{[2
]}

Cai, Yu ^{[1
]}

机构：

[1] Jinan Univ, State Key Lab Bioact Mol & Druggabil Assessment, Int Cooperat Lab Tradit Chinese Med Modernizat & I, Int Sci & Technol Cooperat Base Guangdong Prov,Min, Guangzhou 510632, Guangdong, Peoples R China

[2] Guangzhou Univ Tradit Chinese Med, Zhongshan Hosp Tradit Chinese Med, Zhongshan 528400, Guangdong, Peoples R China

[3] Jinan Univ, Affiliated Hosp 1, Guangzhou 510632, Guangdong, Peoples R China

[4] Univ Havana, Fac Chem, Bioinorgan Lab, Havana 1400, Cuba

[5] Natl Acad Sci Belarus, BI Stepanov Inst Phys, Minsk 220072, BELARUS

[6] Brazilian Nucl Energy Commiss, Nucl Engn Inst, Lab Nanoradiopharm & Synth New Radiopharmaceut, BR-21941906 Rio De Janeiro, RJ, Brazil

[7] Univ Sargodha, Coll Pharm, Sargodha 40100, Punjab, Pakistan

[8] Islamia Univ Bahawalpur, Fac Pharm, Dept Pharmaceut, Bahawalpur 63100, Pakistan

[9] Shenzhen Tradit Chinese Med Hosp, Shenzhen 518033, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2024年 / 19卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Nanopreparations; Organic Nanomaterials; Inorganic Nanomaterials; Surface Engineering; Targeted Delivery; MOLECULARLY IMPRINTED POLYMER; SENTINEL NODE BIOPSY; IMMUNE-RESPONSE; HYALURONIC-ACID; THERAPY; CELLS; NANOCARRIERS; FERUMOXIDES; ENHANCEMENT; METASTASES;

D O I：

10.2147/IJN.S477652

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Data published in 2020 by the International Agency for Research on Cancer (IARC) of the World Health Organization show that breast cancer (BC) has become the most common cancer globally, affecting more than 2 million women each year. The complex tumor microenvironment, drug resistance, metastasis, and poor prognosis constitute the primary challenges in the current diagnosis and treatment of BC. Magnetic iron oxide nanoparticles (MIONPs) have emerged as a promising nanoplatform for diagnostic tumor imaging as well as therapeutic drug-targeted delivery due to their unique physicochemical properties. The extensive surface engineering has given rise to multifunctionalized MIONPs. In this review, the latest advancements in surface modification strategies of MIONPs over the past five years are summarized and categorized as constrast agents and drug delivery platforms. Additionally, the remaining challenges and future prospects of MIONPs-based targeted delivery are discussed.

引用

页码：8437 / 8461

页数：25

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