Sparsentan, the Dual Endothelin Angiotensin Receptor Antagonist (DEARA), Improves Kidney Function and Life Span and Protects Against Hearing Loss in Alport Mice with Developed Renal Structural Changes

被引：0
|
作者：
Cosgrove, Dominic E. [1 ]
Gratton, MichaelAnne [2 ]
Meehan, Daniel T. [1 ]
Vosik, Denise [1 ]
Madison, Jacob D. [1 ]
Delimont, Duane C. [1 ]
Samuelson, Gina C. [1 ]
Jarocki, Diana [2 ]
Komers, Radko [3 ]
Jenkinson, Celia P. [3 ]
机构：
[1] Boys Town Natl Res Hosp, Omaha, NE USA
[2] Washington Univ, St Louis, MO 63110 USA
[3] Travere Therapeut Inc, San Diego, CA USA
来源：
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2021年 / 32卷 / 10期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
PO1299
引用
收藏
页码：417 / 417
页数：1
相关论文
共 3 条
  • [1] The Dual Endothelin Angiotensin Receptor Antagonist (DEARA) Sparsentan Protects from Glomerular Hypercellularity and Associated Immune/Inflammatory Gene Network Activity in a Model of IgA Nephropathy
    Reily, Colin
    Moldoveanu, Zina
    Pramparo, Tiziano
    Hall, Stacy D.
    Novak, Lea
    Komers, Radko
    Jenkinson, Celia P.
    Novak, Jan
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021, 32 (10): : 459 - 459
  • [2] SPARSENTAN, THE DUAL ENDOTHELIN ANGIOTENSIN RECEPTOR ANTAGONIST (DEARA), ATTENUATES ALBUMINURIA AND PROTECTS FROM THE DEVELOPMENT OF RENAL INJURY TO A GREATER EXTENT THAN LOSARTAN IN THE GDDY MOUSE MODEL OF IGA NEPHROPATHY: A 16-WEEK STUDY
    Nagasawa, Hajime
    Suzuki, Hitoshi
    Jenkinson, Celia
    Ueda, Seiji
    Fukao, Yusuke
    Nakayama, Maiko
    Otsuka, Tomoyuki
    Okuma, Teruyuki
    Clapper, Wilmelenne
    Komers, Radko
    Suzuki, Yusuke
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2022, 37 : I183 - I183
  • [3] THE DUAL ETAR/AT1R BLOCKER SPARSENTAN SLOWS RENAL DISEASE, IMPROVES LIFESPAN, AND ATTENUATES HEARING LOSS IN ALPORT MICE: COMPARISON WITH LOSARTAN
    Cosgrove, Dominic
    Dufek, Brianna
    Delimont, Duane
    Meehan, Daniel
    Samuelson, Gina
    Hartsock, Jared
    Phillips, Grady
    Gill, Ruth
    Hasson, James
    Jenkinson, Celia
    Komers, Radko
    Gratton, Michael Anne
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2020, 35 : 133 - 133
1