Synthesis of macrocyclic thiolactone peptides via photochemical intramolecular radical acyl thiol-ene ligation

被引：0
|
作者：
Benny, Alby [1 ]
Scanlan, Eoin M. [1 ]
机构：
[1] Trinity Coll Dublin, Trinity Biomed Sci Inst, 152 160 Pearse St, Dublin, Ireland
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 61期
基金：
爱尔兰科学基金会;
关键词：
SOLID-PHASE SYNTHESIS; STRATEGIES; CHEMISTRY;
D O I：
10.1039/d4cc02442g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A photochemical acyl thiol-ene reaction can be used to rapidly cyclise fully unprotected peptides bearing both a thioacid and alkene to form peptide thiolactones. This strategy represents the first reported synthesis of peptide thiolactones under radical-mediated conditions.
引用
收藏
页码：7950 / 7953
页数：4
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