ackground: Patient navigation interventions (PNIs) can provide personalized support and promote appropriate coordinationor continuation of health and social care services. Online PNIs have demonstrated excellent potential for improving patientknowledge, transition readiness, self-efficacy, and use of services. However, the characteristics (ie, intervention type, mode ofdelivery, duration, frequency, outcomes and outcome measures, underlying theories or mechanisms of change of the intervention,and impact) of existing online PNIs to support the health and social needs of individuals with illness remain unclear.Objective: This scoping review of the existing literature aims to identify the characteristics of existing online PNIs reported inthe literature.Methods: A scoping review based on the guidelines outlined in the Joanna Briggs Institute framework was conducted. A searchfor peer-reviewed literature published between 1989 and 2022 on online PNIs was conducted using MEDLINE, CINAHL, Embase,PsycInfo, and Cochrane Library databases. Two independent reviewers conducted 2 levels of screening. Data abstraction wasconducted to outline key study characteristics (eg, study design, population, and intervention characteristics). The data wereanalyzed using descriptive statistics and qualitative content analysis.Results: A total of 100 studies met the inclusion criteria. Our findings indicate that a variety of study designs are used to describeand evaluate online PNIs, with literature being published between 2003 and 2022 in Western countries. Of these studies, 39 (39%)studies were randomized controlled trials. In addition, we noticed an increase in reported online PNIs since 2019. The majorityof studies involved White females with a diagnosis of cancer and a lack of participants aged 70 years or older was observed. Mostonline PNIs provide support through navigation, self-management and lifestyle changes, counseling, coaching, education, or acombination of support. Variation was noted in terms of mode of delivery, duration, and frequency. Only a small number ofstudies described theoretical frameworks or change mechanisms to guide intervention.Conclusions: To our knowledge, this is the first review to comprehensively synthesize the existing literature on online PNIs,by focusing on the characteristics of interventions and studies in this area. Inconsistency in reporting the country of publication,population characteristics, duration and frequency of interventions, and a lack of the use of underlying theories and workingmechanisms to inform intervention development, provide guidance for the reporting of future online PNIs