The renal function trajectory in clinical trial design: challenges and opportunities

被引：0
|
作者：
Rosansky, Steven [1 ]
Glassock, Richard [2 ]
机构：
[1] Williams Jenning Brian Dorn Vet Adm Hosp, Dorn Res Inst, 6439 Garners Ferry Rd, Columbia, SC 29209 USA
[2] UCLA, David Geffen Sch Med, Dept Med, Los Angeles, CA USA
来源：
KIDNEY INTERNATIONAL | 2024年 / 106卷 / 04期
关键词：
D O I：
10.1016/j.kint.2024.07.023
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The changes in renal function over time as surrogate endpoints for new drug trials are complicated by many factors, including the oftenexpected initial decrease in estimated glomerular filtration rate when a new drug is started. Two articles in the journal address this challenge, but multiple other challenges are explored in this commentary. To maximize the benefits of expensive new drugs that may slow decline in renal function, these drugs should be reserved for those patients who have a high probability of rapid loss of kidney function.
引用
收藏
页码：565 / 568
页数：4
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