Catalytic atroposelective electrophilic amination of diaryl anilines and diaryl phenols for the synthesis of axially chiral diaryl compounds

Disclosed here is a chiral phosphoric acid-catalyzed atroposelective electrophilic amination reaction, which provides access to a series of axially chiral diaryl compounds through the desymmetric amination reactions of diaryl anilines and diaryl phenols with azodiformates as electrophilic reagents. The reaction could be carried out at room temperature and provide the products with excellent yield and enantioselectivity. A CPA-catalyzed atroposelective electrophilic amination reaction has been developed, which provides access to a series of axially chiral diaryl compounds through the desymmetric amination reactions of diaryl anilines/phenols with azodiformates.