Objective: With the increase in the availability of data on the web, the number of research studies in the digital environment, especially those using data from cultural heritage, is also growing in the field of Humanities and Social Sciences. In this sense, this article aims to investigate the challenges faced by Knowledge Organization in the context Digital Humanities and Cultural Heritage. For this purpose, publications in the area of "Information and Computing Sciences" in the Dimensions database are analyzed. Methods: This study is qualitative, descriptive and exploratory, with data collection performed on the Dimensions database. After exporting to spreadsheets, bibliometric maps were created in VOSViewer using data from 477 articles. The analysis allowed the identification of 5 clusters, of which 2 address challenges for Knowledge Organization. Results: Among the main challenges identified are the management of heterogeneous data from Cultural Heritage, which are fragmented across several repositories of smaller projection and scope. The digital representation of Cultural Heritage data is another important challenge, both in terms of machine processing and human user experience. These problems make it difficult to contextualize and enrich information for and by users, requiring integration and interoperability of the repositories' collections. The integration of heterogeneous datasets of cultural heritage is a common problem in Digital Humanities. The results indicate that current solutions are not sufficient to handle the complexity of the data. Conclusions: The results indicate that current solutions are not sufficient to cope with the complexity of data, which highlights the need to identify, investigate, and produce knowledge about these challenges, providing visibility for them to be addressed and tackled. Data integration, the use of controlled vocabularies, and Linked Data represent important processes and technologies for promoting semantic interoperability and significant advances in the areas of Digital Humanities and Cultural Heritage. As a future work, the objective is to focus on initiatives that deal with data integration and to continue investigating Knowledge Organization in the context of Digital Humanities and Cultural Heritage