Managing Post-Transplant Diabetes Mellitus after Kidney Transplantation: Challenges and Advances in Treatment

被引:0
|
作者
Rudzki, Grzegorz [1 ]
Knop-Chodyla, Kinga [2 ]
Piasecka, Zuzanna [3 ]
Kochanowska-Mazurek, Anna [4 ]
Glaz, Aneta [5 ]
Wesolek-Bielaska, Ewelina [2 ]
Wozniak, Magdalena [1 ]
机构
[1] Med Univ Lublin, Dept Endocrinol Diabetol & Metab Dis, Jaczewskiego 8, PL-20954 Lublin, Poland
[2] Univ Clin Hosp 4, Jaczewskiego 8, PL-20954 Lublin, Poland
[3] St Queen Jadwigas Reg Clin Hosp 2, Lwowska 60, PL-35301 Rzeszow, Poland
[4] Stefan Cardinal Wyszynski Prov Specialist Hosp, al Krasnicka 100, PL-20718 Lublin, Poland
[5] Med Univ Lublin, Fac Med, al Raclawickie 1, PL-20059 Lublin, Poland
关键词
diabetes mellitus; hyperglycemia; kidney transplantation; insulin resistance; post-transplant diabetes mellitus; new onset diabetes after transplantation; RENAL-TRANSPLANTATION; DOUBLE-BLIND; ONSET; MANAGEMENT; RECIPIENTS; TACROLIMUS; PREVENTION; IMMUNOSUPPRESSION; LIRAGLUTIDE; TIRZEPATIDE;
D O I
10.3390/ph17080987
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Kidney transplantation is the most effective treatment for end-stage renal failure but is associated with complications, including post-transplant diabetes mellitus (PTDM). It affects the quality of life and survival of patients and the transplanted organ. It can cause complications, including infections and episodes of acute rejection, further threatening graft survival. The prevalence of PTDM, depending on the source, can range from 4 to 30% in transplant patients. This article aims to discuss issues related to diabetes in kidney transplant patients and the latest treatments. Knowledge of the mechanisms of action of immunosuppressive drugs used after transplantation and their effect on carbohydrate metabolism is key to the rapid and effective detection of PTDM. Patient therapy should not only include standard management such as lifestyle modification, insulin therapy or pharmacotherapy based on well-known oral and injection drugs. New opportunities are offered by hypoglycemic drugs still in clinical trials, including glucokinase activators, such as dorzagliatin, ADV-1002401, LY2608204, TMG-123, imeglimine, amycretin and pramlintide. Although many therapeutic options are currently available, PTDM often creates uncertainty about the most appropriate treatment strategy. Therefore, more research is needed to individualize therapeutic plans and monitor these patients.
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页数:18
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