Kidney transplantation is the most effective treatment for end-stage renal failure but is associated with complications, including post-transplant diabetes mellitus (PTDM). It affects the quality of life and survival of patients and the transplanted organ. It can cause complications, including infections and episodes of acute rejection, further threatening graft survival. The prevalence of PTDM, depending on the source, can range from 4 to 30% in transplant patients. This article aims to discuss issues related to diabetes in kidney transplant patients and the latest treatments. Knowledge of the mechanisms of action of immunosuppressive drugs used after transplantation and their effect on carbohydrate metabolism is key to the rapid and effective detection of PTDM. Patient therapy should not only include standard management such as lifestyle modification, insulin therapy or pharmacotherapy based on well-known oral and injection drugs. New opportunities are offered by hypoglycemic drugs still in clinical trials, including glucokinase activators, such as dorzagliatin, ADV-1002401, LY2608204, TMG-123, imeglimine, amycretin and pramlintide. Although many therapeutic options are currently available, PTDM often creates uncertainty about the most appropriate treatment strategy. Therefore, more research is needed to individualize therapeutic plans and monitor these patients.
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Sci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, RussiaSci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, Russia
Anisimov, Y.
Lasareva, K.
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Sci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, RussiaSci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, Russia
Lasareva, K.
Storozhev, R.
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Sci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, RussiaSci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, Russia
Storozhev, R.
Pinchuk, A.
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Sci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, RussiaSci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, Russia
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Sci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, RussiaSci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, Russia
Anisimov, Y.
Lasareva, K.
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Sci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, RussiaSci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, Russia
Lasareva, K.
Storozhev, R.
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Sci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, RussiaSci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, Russia
Storozhev, R.
Pinchuk, A.
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Sci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, RussiaSci Res Inst Emergency Care, Dept Pancreas & Kidney Transplantat, Moscow, Russia
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Thomas Jefferson Univ Hosp, Dept Med, Div Nephrol, 833 Chestnut St,Suite 700, Philadelphia, PA 19107 USAThomas Jefferson Univ Hosp, Dept Med, Div Nephrol, 833 Chestnut St,Suite 700, Philadelphia, PA 19107 USA
Cantarin, Maria P. Martinez
Keith, Scott W.
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Thomas Jefferson Univ, Dept Pharmacol & Expt Therapeut, Div Biostat, Philadelphia, PA USAThomas Jefferson Univ Hosp, Dept Med, Div Nephrol, 833 Chestnut St,Suite 700, Philadelphia, PA 19107 USA
Keith, Scott W.
Lin, Zhao
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Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Med Oncol, Philadelphia, PA USAThomas Jefferson Univ Hosp, Dept Med, Div Nephrol, 833 Chestnut St,Suite 700, Philadelphia, PA 19107 USA
Lin, Zhao
Doria, Cataldo
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Thomas Jefferson Univ Hosp, Dept Surg, Div Transplantat, Philadelphia, PA USAThomas Jefferson Univ Hosp, Dept Med, Div Nephrol, 833 Chestnut St,Suite 700, Philadelphia, PA 19107 USA
Doria, Cataldo
Frank, Adam M.
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Thomas Jefferson Univ Hosp, Dept Surg, Div Transplantat, Philadelphia, PA USAThomas Jefferson Univ Hosp, Dept Med, Div Nephrol, 833 Chestnut St,Suite 700, Philadelphia, PA 19107 USA
Frank, Adam M.
Maley, Warren R.
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Thomas Jefferson Univ Hosp, Dept Surg, Div Transplantat, Philadelphia, PA USAThomas Jefferson Univ Hosp, Dept Med, Div Nephrol, 833 Chestnut St,Suite 700, Philadelphia, PA 19107 USA
Maley, Warren R.
Ramirez, Carlo
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Thomas Jefferson Univ Hosp, Dept Surg, Div Transplantat, Philadelphia, PA USAThomas Jefferson Univ Hosp, Dept Med, Div Nephrol, 833 Chestnut St,Suite 700, Philadelphia, PA 19107 USA
Ramirez, Carlo
Lallas, Costas D.
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Thomas Jefferson Univ Hosp, Dept Urol, Philadelphia, PA USAThomas Jefferson Univ Hosp, Dept Med, Div Nephrol, 833 Chestnut St,Suite 700, Philadelphia, PA 19107 USA
Lallas, Costas D.
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Shah, Ashesh
Waldman, Scott A.
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Thomas Jefferson Univ, Dept Pharmacol & Expt Therapeut, Div Biostat, Philadelphia, PA USAThomas Jefferson Univ Hosp, Dept Med, Div Nephrol, 833 Chestnut St,Suite 700, Philadelphia, PA 19107 USA