Wnt/(3-catenin signaling in corneal epithelium development, homeostasis, and pathobiology

被引：0
|
作者：
Wang, Yihui [1 ]
Ge, Huanhuan [1 ]
Chen, Peng [1 ,3 ]
Wang, Ye [2 ]
机构：
[1] Qingdao Univ, Sch Basic Med, Qingdao 266071, Shandong, Peoples R China
[2] Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, Qingdao Cent Med Grp, Qingdao 266042, Shandong, Peoples R China
[3] Qingdao Univ, Inst Stem Cell Regenerat Med, Sch Basic Med, Qingdao 266071, Peoples R China
来源：
EXPERIMENTAL EYE RESEARCH | 2024年 / 246卷
基金：
中国国家自然科学基金;
关键词：
Wnt/(3-catenin; Corneal epithelium; Development; Homeostasis; Pathobiology; WNT/BETA-CATENIN; BETA-CATENIN; CELL-PROLIFERATION; DOWN-REGULATION; WNT PATHWAY; TGF-BETA; REGULATES PROLIFERATION; LENS MORPHOGENESIS; LIMBAL EPITHELIUM; STEM-CELLS;
D O I：
10.1016/j.exer.2024.110022
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The corneal epithelium is located on the most anterior surface of the eyeball and protects against external stimuli. The development of the corneal epithelium and the maintenance of corneal homeostasis are essential for the maintenance of visual acuity. It has been discovered recently via the in-depth investigation of ocular surface illnesses that the Wnt/(3-catenin (3- catenin signaling pathway is necessary for the growth and stratification of corneal epithelial cells as well as the control of endothelial cell stability. In addition, the Wnt/(3-catenin (3- catenin signaling pathway is directly linked to the development of common corneal illnesses such as keratoconus, fungal keratitis, and corneal neovascularization. This review mainly summarizes the role of the Wnt/(3-catenin (3- catenin signaling pathway in the development, homeostasis, and pathobiology of cornea, hoping to provide new insights into the study of corneal epithelium and the treatment of related diseases.
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页数：12
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