Advancements in Long-Acting Injectable Therapies: Revolutionizing Cancer Treatment

This review aims to explore the advancements in long-acting injectable therapies [LAI] that are revolutionizing cancer treatment. With cancer posing a significant global health challenge, conventional treatments often come with limitations, including harmful side effects and resistance development. Long-acting formulations (LAFs), particularly those manipulating medication release through delivery systems, present a promising alternative. The review delves into various LAF approaches, such as micro-encapsulation, liposomes, oil-based LAPFs, nanocrystal suspensions, long-acting hydrogels, microneedles, and implantable systems. These approaches offer sustained release, reduced toxicity, and improved therapeutic efficacy. The review highlights the benefits and disadvantages of LAIs, emphasizing improved adherence, reduced risk of relapse, and enhanced quality of life. Evaluation parameters, including pharmacokinetics, biocompatibility, stability, mechanical properties, and safety, are discussed. The comprehensive assessment underscores the ongoing efforts in oncological research to develop innovative and effective therapies that address the challenges associated with conventional cancer treatments.