Impact of prematurity on LINE-1 promoter methylation

被引：0
|
作者：
dos Santos, Paulo Victor Barbosa Eleuterio [1 ,2 ]
Brasil, Aline de Araujo [1 ]
Milone, Leo Travassos Vieira [1 ,3 ]
Chalfun, Georgia [1 ,4 ]
Saide, Stephanie Cristina Alves de Oliveira [1 ,3 ]
Salu, Margarida dos Santos [1 ]
de Oliveira, Mariana Barros Genuino [1 ]
Robaina, Jaqueline Rodrigues [1 ]
Lima-Setta, Fernanda [1 ]
Rodrigues-Santos, Gustavo [1 ]
de Magalhaes-Barbosa, Maria Clara [1 ]
da Cunha, Antonio Jose Ledo Alves [1 ,2 ]
Prata-Barbosa, Arnaldo [1 ,2 ]
机构：
[1] DOr Inst Res & Educ IDOR, Dept Pediat, Rio De Janeiro, RJ, Brazil
[2] Fed Univ Rio De Janeiro UFRJ, Martagao Gesteira Inst Childcare & Pediat IPPMG, Rio De Janeiro, Brazil
[3] Fed Univ Rio De Janeiro UFRJ, Inst Genet, Rio De Janeiro, Brazil
[4] Fed Univ Rio De Janeiro UFRJ, Matern Sch, Dept Neonatol, BR-22240000 Rio De Janeiro, RJ, Brazil
来源：
EPIGENOMICS | 2024年
关键词：
DNA methylation; epigenetics; LINE-1; newborn; prematurity; retroelements; DNA METHYLATION; ELEMENTS;
D O I：
10.1080/17501911.2024.2397329
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: Promoter methylation of LINE-1 may be affected by prematurity, but there is little evidence in the literature. Materials & methods: Blood from premature and full-term neonates on days 0, 5, 30 and 90 was analyzed for DNA methylation percentage in a promoter region of the LINE-1, after bisulfite conversion and pyrosequencing. Results: Premature infants, as a whole, showed significantly lower methylation percentage at birth, but this difference diminished over time. However, the subgroup of extremely premature (<28 weeks gestational age) had higher methylation percentages, similar to full-term newborns. Conclusion: This research underscores the critical role of prematurity on the methylation pattern of LINE-1. These findings underline the complexity of epigenetic regulation in prematurity and emphasize the need for further studies.
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页数：12
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