A Serum Multi-Parametric Analysis Identifies an Early Innate Immune Signature Associated to Increased Vaccine-Specific Antibody Production and Seroconversion in Simultaneous COVID-19 mRNA and Cell-Based Quadrivalent Influenza Vaccination

被引：0

作者：

Severa, Martina ^{[1
]}

Ricci, Daniela ^{[1
]}

Etna, Marilena Paola ^{[1
]}

Facchini, Marzia ^{[1
]}

Puzelli, Simona ^{[1
]}

Fedele, Giorgio ^{[1
]}

Iorio, Egidio ^{[2
]}

Cairo, Giada ^{[1
]}

Castrechini, Sara ^{[3
]}

Ungari, Valentina ^{[3
]}

Iannetta, Marco ^{[4
]}

Leone, Pasqualina ^{[1
]}

Chirico, Mattea ^{[2
]}

Pisanu, Maria Elena ^{[2
]}

Bottazzi, Barbara ^{[5
]}

Benedetti, Livia ^{[4
]}

Sali, Michela ^{[6
,7
]}

Bartolomucci, Remo ^{[3
]}

Balducci, Stefano ^{[8
]}

Garlanda, Cecilia ^{[5
,9
]}

Stefanelli, Paola ^{[1
]}

Spadea, Antonietta ^{[3
]}

Palamara, Anna Teresa ^{[1
]}

Coccia, Eliana Marina ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Infect Dis, I-00161 Rome, Italy

[2] Ist Super Sanita, High Resolut NMR Unit, Core Facil, I-00161 Rome, Italy

[3] ASL ROMA 1, I-00145 Rome, Italy

[4] Tor Vergata Univ Hosp, Infect Dis Clin, I-00133 Rome, Italy

[5] Human Clin & Res Ctr IRCCS, Dept Inflammat & Immunol, I-20019 Milan, Italy

[6] Fdn Policlin Univ A Gemelli IRCCS, Dept Lab & Infect Sci, I-00168 Rome, Italy

[7] Univ Cattolica Sacro Cuore, Dept Basic Biotechnol Sci, Intens & Perioperat Clin, I-00168 Rome, Italy

[8] Metab Fitness Assoc, I-00015 Rome, Italy

[9] Humanitas Univ, Dept Biomed Sci, Milan, Italy

来源：

VACCINES | 2024年 / 12卷 / 09期

关键词：

COVID-19; influenza virus; vaccination; innate immunity; metabolism; SEASONAL INFLUENZA; RECOGNITION; IMMUNOGENICITY; RESPONSES; SAFETY; PTX3;

D O I：

10.3390/vaccines12091050

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this pilot study, a multi-parametric analysis comparing immune responses in sera of adult healthy subjects (HS) or people with type 2 diabetes mellitus (T2D) undergoing the single or simultaneous administration of mRNA-based COVID-19 and cellular quadrivalent inactivated influenza vaccines was conducted. While SARS-CoV-2 antibodies remains comparable, influenza antibody titers and seroconversion were significantly higher upon simultaneous vaccination. Magnitude of anti-influenza humoral response closely correlated with an early innate immune signature, previously described for the COVID-19 vaccine, composed of IL-15, IL-6, TNF-alpha, IFN-gamma, CXCL-10 and here extended also to acute-phase protein Pentraxin 3. People with T2D receiving simultaneous vaccination showed a protective response comparable to HS correlating with the early induction of IFN-gamma/CXCL10 and a significant reduction of the circulating glucose level due to increased oxidation of glucose digestion and consumption. These data, although preliminary and in-need of validation in larger cohorts, might be exploited to optimize future vaccination in people with chronic disorders, including diabetes.

引用

页数：25