Long-Term Follow-Up of Descemet Stripping Only: Data Up to 7 Years Postoperatively

Purpose:The aim of this study was to report long-term follow-up of eyes undergoing Descemet stripping only (DSO). Methods:This was a retrospective study including 26 eyes of 20 patients undergoing DSO between December 2015 and November 2022. Eligibility criteria included peripheral endothelial cell count (ECC) >1000 cells/mm2 and symptoms caused by central guttata. Patients underwent a central circular 4-mm descemetorhexis using a reverse Sinskey hook and a pair of descemetorhexis forceps using a peeling technique. Three parameters were measured before surgery and at last follow-up: best-corrected visual acuity (BCVA), central corneal thickness (CCT), and ECC measured centrally and at the periphery. Results:The mean age was 73 +/- 9 years [52-90 years]. The average follow-up period was 23.7 +/- 24.8 months [3-84]. Twenty-two eyes responded to DSO with 20 female eyes (91%) and 2 male eyes (9%). The mean postoperative BCVA improved from 0.3 +/- 0.17 logMAR to 0.09 +/- 0.13 logMAR (P value <0.05). The mean postoperative CCT decreased from 588 +/- 41 mu m to 546 +/- 50 mu m (P-value <0.05). The mean postoperative central ECC was 780 +/- 257 cells/mm2 [484-1500]. Peripheral ECC decreased postoperatively (1837 +/- 407 cells/mm2 preoperatively to 864 +/- 340 cells/mm2 postoperatively, P value >0.05). Peripheral endothelial cell polymegathism was stable (average of 26.8% +/- 6.8% preoperatively and 30.2% +/- 14% postoperatively). Average peripheral endothelial cells polymorphism decreased postoperatively (63.1 +/- 20.5% preoperatively to 33% +/- 25% postoperatively, P value >0.05). Four eyes did not show improvement after DSO and underwent Descemet membrane endothelial keratoplasty surgery. There were 3 men (75%) and 1 women (25%). The preoperative trend was for nonresponders to have lower BCVA, higher CCT, more abnormal peripheral polymorphism, and polymegathism. Conclusions:The results of this study, with up to 7 years follow up, demonstrate the durability of DSO.