Effects of Platelet-Rich Plasma Injections on Periodontal Health During Accelerated Orthodontic Tooth Movement

Background: The interplay between orthodontics and periodontics is crucial for successful orthodontic treatment. Accelerating orthodontic tooth movement (OTM) can enhance treatment efficiency, but it is important to assess the impact of such methods on periodontal health. Platelet-rich plasma (PRP) has emerged as a promising adjunct in accelerating OTM, but its effects on periodontal health require further investigation. Objective: This study aimed to evaluate the impact of PRP injections on periodontal health during accelerated OTM by comparing clinical and biochemical parameters between a PRP-enhanced orthodontic treatment group and a conventional orthodontic treatment group. Methods: In this randomized controlled trial, 40 participants with anterior teeth crowding were divided into two groups: the PRP group (n = 20), which received standard orthodontic treatment with PRP injections, and the control group (n = 20), which received standard orthodontic treatment alone. Periodontal parameters, including periodontal probing depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), and gingival recession (GR), were recorded at baseline, four, eight, and 12 weeks. Salivary aspartate aminotransferase (AST) levels were measured at baseline, one hour, 24 hours, seven days, and 14 days post treatment.<br /> Results: No statistically significant differences were found between the PRP and control groups regarding periodontal parameters (PPD, CAL, BOP, and GR) and AST enzyme levels throughout the study period. Both groups exhibited slight increases in PPD, CAL, GR, and BOP over time, consistent with typical orthodontic effects. AST levels showed fluctuations but no significant differences between the groups.<br /> Conclusion: PRP injections did not demonstrate significant advantages over conventional orthodontic treatment in terms of periodontal health or AST enzyme levels. This suggests that PRP is a safe and non- inferior method for accelerating OTM without adversely affecting periodontal tissues. Further research with larger sample sizes and longer follow-ups is recommended to validate these findings and explore the longterm effects of PRP.