Functionalized α-Fluorinated Amines from Imines and Enol Ethers

被引：1

作者：

Kyrko, Dimitra ^{[1
]}

Sarac, Murat ^{[1
]}

Hao, Jing ^{[1
]}

Retailleau, Pascal ^{[2
]}

Ongeri, Sandrine ^{[1
]}

Crousse, Benoit ^{[1
]}

机构：

[1] Univ Paris Saclay, CNRS, UMR 8076, BioCIS, Bldg Henri Moissan,17 Ave Sci, F-91400 Orsay, France

[2] Univ Paris Saclay, Inst Chim Subst Nat, CNRS, F-91198 Gif sur Yvette, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 16期

关键词：

Enol ethers; Amines; Fluoroalkyl groups; Amino alcohols; Pyrrolidines; ACID-DERIVATIVES; SILYL ACETAL; TRIFLUOROMETHYLATION; CHEMISTRY; ANALOGS; METHYL;

D O I：

10.1002/adsc.202400517

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We report the addition reaction of lithium enol ethers to fluoroalkyl imines. A range of different fluoroalkyls and lithiated reagents are well tolerated. Diastereoselective addition of lithium vinyl ethers to fluoroalkyl N-tert-butylsulfinylimines is disclosed, providing enantiomerically enriched alpha-fluorinated amines in up to 98% yield. This general approach led to the diastereoselective formation of various amino alcohols and amino ethers, which are difficult to obtain by other methods. image

引用

页码：3460 / 3465

页数：6

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