Electrochemical Non-Directed Arene C-H Amination

Electrosynthesis represents a dynamic field in organic chemistry for the development of important and selective reactions. Among the most interesting electrosynthetic transformations is the non-directed arene C-H amination. Despite increasing reports, the quest for a non-directed electrochemical arene C-H amination capable of accommodating a wide range of arenes and amines with high site-selectivity remains ongoing. Non-directed electrochemical C-H amination presents a metal-free, mild approach for synthesizing complex aminated compounds of interest in pharmaceuticals and natural products. This concept aims to introduce the concept of non-directed electrochemical C-H amination and provide an overview of the recent advances in the field as well as the current limitations and potential directions. Electrosynthesis is transforming organic chemistry with innovative reactions such as non-directed arene C-H amination. This sustainable approach converts aromatic C-H bonds aromatic amines, crucial for pharmaceuticals and natural products. Despite progress, achieving high site-selectivity and broad arene scope remains challenging. This overview explores recent advances, current limitations, and future directions in this promising field. image