One Pot Tandem P-Michael Addition/SN2/Intramolecular Wittig Reaction of aza-o-Quinone Methides: Construction of 2,3-Disubstituted Dihydroquinoline Derivatives

被引：1
|
作者：
Liu Yudi [1 ]
Cheng Hang [1 ]
He Zhaolin [1 ]
Chen Wei [1 ]
机构：
[1] Wuhan Inst Technol, Sch Chem & Environm Engn, Hubei Key Lab Novel Reactor & Green Chem Technol, Wuhan 430205, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 44卷 / 07期
基金：
中国国家自然科学基金;
关键词：
aza-o-quinone methides; dihydroquinoline derivatives; quinoline derivatives; 4+2 CYCLOADDITION; CYCLIZATION;
D O I：
10.6023/cjoc202402002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot tandem P-Michael addition/S(N)2/intramolecular Wittig Reaction of in situ generated aza-o-quinone methides with PPh3 and alpha-bromo ketones has been reported. This protocol provided an efficient and mild approach to synthesize 2,3-disubstituted dihydroquinolines in 25%similar to 93% yields. In addition, the 2,3-disubstituted quinolines could also be obtained by simply modification of the reaction conditions.
引用
收藏
页码：2241 / 2250
页数：10
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