Light-Controlled Regulation of Dual-Enzyme Properties in YbGd-Carbon Quantum Dots Nano-Hybrid for Advanced Biosensing

被引：3

作者：

Li, Guoming ^{[1
]}

Yang, Jing ^{[1
]}

Zhang, Yuanyuan ^{[1
]}

Li, Haiyan ^{[1
]}

Deng, Keqin ^{[1
]}

Huang, Haowen ^{[1
]}

机构：

[1] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Theoret Organ Chem & Funct Mol, Hunan Prov Key Lab Controllable Preparat & Funct A, Xiangtan 411201, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2024年 / 96卷 / 33期

关键词：

D O I：

10.1021/acs.analchem.4c01560

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Compared to nanozymes with single enzyme activity, those with multiple enzyme activities possess broader application potential due to their diversified enzymatic functionalities. However, the multienzyme nanozymes currently face challenges of interference among different enzymatic activities during practical applications. In this study, we report the synthesis of a light-responsive YbGd-carbon quantum dots nano-hybrid, termed YbGd-CDs, which exhibits controllable enzyme-mimicking activities. This light-responsive behavior enables selective control of the enzymatic activities. Under visible light irradiation, YbGd-CDs demonstrate robust oxidase-like activity. Conversely, under dark conditions, they primarily exhibit peroxidase-like activity. Leveraging the dual-enzyme-mimicking capabilities of YbGd-CDs, we developed colorimetric assays for sensitive detection of total antioxidant capacity (TAC) in both normal and cancer cells as well as d-amino acids in human saliva. This study not only advances the synthesis of carbon-based nanozymes but also highlights their potential in biosensing applications.

引用

页码：13455 / 13463

页数：9