Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives

被引：0
|
作者：
Zhang, Min [1 ,2 ,3 ]
Mi, Man [1 ,2 ,4 ]
Hu, Zilong [3 ,4 ]
Li, Lixian [3 ,4 ]
Chen, Zhiping [1 ,2 ,3 ]
Gao, Xiang [5 ]
Liu, Di [3 ,4 ]
Xu, Bilian [3 ]
Liu, Yanzhi [1 ,2 ,3 ]
机构：
[1] Guangdong Med Univ, Zhanjiang Cent Hosp, Zhanjiang Key Lab Orthopaed Technol & Trauma Treat, Zhanjiang 524037, Peoples R China
[2] Cent Peoples Hosp Zhanjiang, Key Lab Tradit Chinese Med Prevent & Treatment Inf, Guangdong Prov Adm Tradit Chinese Med, Zhanjiang 524037, Peoples R China
[3] Guangdong Med Univ, Marine Med Res Inst Zhanjiang, Sch Ocean & Trop Med, Zhanjiang 524023, Peoples R China
[4] Guangdong Med Univ, Sch Pharm, Guangdong Prov Key Lab Res & Dev Nat Drug, Zhanjiang 524023, Peoples R China
[5] Guangdong Med Univ, Affiliated Hosp, Stem Cell Res & Cellular Therapy Ctr, Zhanjiang 524001, Guangdong, Peoples R China
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2024年 / 18卷
基金：
中国国家自然科学基金;
关键词：
polydopamine; biomaterials; nanoparticles; bone; orthopaedics; MUSSEL-INSPIRED POLYDOPAMINE; MEDIATED SURFACE MODIFICATION; POLY(LACTIC ACID) SCAFFOLDS; SELECTIVE PHYSICAL PUNCTURE; MESENCHYMAL STEM-CELLS; OSTEOGENIC DIFFERENTIATION; IN-VITRO; ANTIBACTERIAL ACTIVITY; BONE-FORMATION; POLY(DOPAMINE)-ASSISTED IMMOBILIZATION;
D O I：
10.2147/DDDT.S473007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Polydopamine is a versatile and modifiable polymer, known for its excellent biocompatibility and adhesiveness. It can also be engineered into a variety of nanoparticles and biomaterials for drug delivery, functional modification, making it an excellent choice to enhance the prevention and treatment of orthopedic diseases. Currently, the application of polydopamine biomaterials in orthopedic disease prevention and treatment is in its early stages, despite some initial achievements. This article aims to review these applications to encourage further development of polydopamine for orthopedic therapeutic needs. We detail the properties of polydopamine and its biomaterial types, highlighting its superior performance in functional modification on nanoparticles and materials. Additionally, we also explore the challenges and future prospects in developing optimal polydopamine biomaterials for clinical use in orthopedic disease prevention and treatment.
引用
收藏
页码：3765 / 3790
页数：26
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