Overview of dyslipidemia and metabolic syndrome in myeloproliferative neoplasms

被引：0

作者：

Gaman, Mihnea-Alexandru ^{[1
,2
,3
]}

Srichawla, Bahadar Singh ^{[4
]}

Chen, Yong-Feng ^{[5
]}

Roy, Poulami ^{[6
]}

Dhali, Arkadeep ^{[7
]}

Nahian, Ahmed ^{[8
]}

Manan, Muhammad Romail ^{[9
]}

Kipkorir, Vincent ^{[10
]}

Suteja, Richard Christian ^{[11
]}

Simhachalam Kutikuppala, Lakshmi Venkata ^{[12
]}

Gaman, Amelia Maria ^{[13
,14
]}

Diaconu, Camelia Cristina ^{[15
,16
]}

机构：

[1] Carol Davila Univ Med & Pharm, Fac Med, Bucharest 050474, Romania

[2] Fundeni Clin Inst, Ctr Hematol & Bone Marrow Transplantat, Dept Hematol, Bucharest 022328, Romania

[3] Romanian Acad, Stefan S Nicolau Inst Virol, Dept Cellular & Mol Pathol, Bucharest 030304, Romania

[4] Univ Massachusetts, Chan Med Sch, Dept Neurol, Worcester, MA 01655 USA

[5] Taizhou Univ, Dept Basic Med Sci, Sch Med, Taizhou 318000, Zhejiang, Peoples R China

[6] North Bengal Med Coll & Hosp, Dept Med, Darjeeling 734012, W Bengal, India

[7] Sheffield Teaching Hosp NHS Fdn Trust, Acad Dept Gastroenterol, Sheffield S5 7AU, England

[8] Lecom Seton Hill, Greensburg, PA 15601 USA

[9] Serv Hosp, Fac Med, Lahore 54000, Pakistan

[10] Univ Nairobi, Dept Human Anat & Physiol, Nairobi 00100, Kenya

[11] Udayana Univ, Fac Med, Denpasar 80361, Bali, Indonesia

[12] Dr NTR Univ Hlth Sci, Dept Gen Surg, Vijayawada 520008, Andhra Pradesh, India

[13] Univ Med & Pharm Craiova, Dept Pathophysiol, Petru Rares No 2, Craiova 200349, Romania

[14] Filantropia City Hosp, Clin Hematol, Craiova 200143, Romania

[15] Carol Davila Univ Med & Pharm, Fac Med, Dept Internal Med, Bucharest 050474, Romania

[16] Clin Emergency Hosp Bucharest, Internal Med Clin, Bucharest 105402, Romania

来源：

WORLD JOURNAL OF CLINICAL ONCOLOGY | 2024年 / 15卷 / 06期

关键词：

Polycythemia vera; Essential thrombocythemia; Myelofibrosis; Cardiovascular disease; Hypercholesterolemia; Hypertriglyceridemia; Obesity; Diabetes; Inflammation; Oxidative stress; JAK-STAT PATHWAY; OXIDATIVE STRESS; ESSENTIAL THROMBOCYTHEMIA; CHRONIC INFLAMMATION; POLYCYTHEMIA-VERA; ACCELERATED ATHEROSCLEROSIS; CLONAL HEMATOPOIESIS; CANCER; MYELOFIBROSIS; EPIDEMIOLOGY;

D O I：

10.5306/wjco.v15.i6.717

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myeloproliferative neoplasms (MPNs) occur due to the abnormal proliferation of one or more terminal myeloid cell lines in peripheral blood. Subjects suffering from MPNs display a high burden of cardiovascular risk factors, and thrombotic events are often the cause of death in this population of patients. Herein, we provide a brief overview of dyslipidemia and metabolic syndrome and their epidemiology in MPNs and examine the common molecular mechanisms between dyslipidemia, metabolic syndrome, and MPNs, with a special focus on cardiovascular risk, atherosclerosis, and thrombotic events. Furthermore, we investigate the impact of dyslipidemia and metabolic syndrome on the occurrence and survival of thrombosis in MPN patients, as well as the management of dyslipidemia in MPNs, and the impact of MPN treatment on serum lipid concentrations, particularly as side/adverse effects reported in the context of clinical trials.

引用

页数：14

共 50 条

[1] Renal disease associated with myeloproliferative neoplasms and myelodysplastic syndrome/myeloproliferative neoplasms
Buettner-Herold, Maike
Sticht, Carsten
Wiech, Thorsten
Porubsky, Stefan
HISTOPATHOLOGY, 2021, 78 (05) : 738 - 748
[2] Myeloproliferative neoplasms and pregnancy: Overview and practice recommendations
Gangat, Naseemap
Tefferi, Ayalew
AMERICAN JOURNAL OF HEMATOLOGY, 2021, 96 (03) : 354 - 366
[3] Emergence of the metabolic syndrome in childhood: an epidemiological overview and mechanistic link to dyslipidemia
Kohen-Avramoglu, R
Theriault, A
Adeli, K
CLINICAL BIOCHEMISTRY, 2003, 36 (06) : 413 - 420
[4] Dyslipidemia and the metabolic syndrome
Bloomgarden, ZT
DIABETES CARE, 2004, 27 (12) : 3009 - 3016
[5] Dyslipidemia and metabolic syndrome
Fuehrer, Dagmar
Reincke, Martin
INNERE MEDIZIN, 2023, 64 (07): : 609 - 610
[6] Dyslipidemia of the metabolic syndrome
Ruotolo G.
Howard B.V.
Current Cardiology Reports, 2002, 4 (6) : 494 - 500
[7] Metabolic Vulnerabilities and Epigenetic Dysregulation in Myeloproliferative Neoplasms
Sharma, Vasundhara
Wright, Kenneth L.
Epling-Burnette, Pearlie K.
Reuther, Gary W.
FRONTIERS IN IMMUNOLOGY, 2020, 11
[8] Characterizing the Metabolic Determinants of Thromboinflammation in Myeloproliferative Neoplasms
Esparza, Orlando
McMahon, Brandon
Hernandez, Giovanny
Nemkov, Travis
D'Alessandro, Angelo
Davizon-Castillo, Pavel
BLOOD, 2021, 138
[9] Metabolic syndrome and dyslipidemia in youth
McNeal, Catherine
Wilson, Don P.
JOURNAL OF CLINICAL LIPIDOLOGY, 2008, 2 (03) : 147 - 155
[10] Metabolic syndrome: Focus on dyslipidemia
Ginsberg, Henry N.
Zhang, Yuan-Li
Hernandez-Ono, Antonio
OBESITY, 2006, 14 : 41S - 49S

← 1 2 3 4 5 →