An in-depth analysis of COVID-19 treatment: Present situation and prospects

被引:0
|
作者
Islam, Md Ariful [1 ]
Pathak, Kalyani [1 ]
Saikia, Riya [1 ]
Pramanik, Pallab [1 ]
Das, Aparoop [1 ]
Talukdar, Prasenjit [2 ]
Shakya, Anshul [1 ]
Ghosh, Surajit Kumar [1 ]
Singh, Udaya Pratap [3 ]
Bhat, Hans Raj [1 ]
机构
[1] Dibrugarh Univ, Dept Pharmaceut Sci, Dibrugarh 786004, Assam, India
[2] University, Dept Petr Engn, DUIET, Dibrugarh, Assam, India
[3] Sam Higginbottom Univ Agr Technol & Sci, Dept Pharmaceut Sci, Drug Design & Discovery Lab, Allahabad, Uttar Pradesh, India
关键词
COVID-19; current status; repurposed drugs; vaccines; ANTI-INTERLEUKIN-6 RECEPTOR ANTIBODY; RESPIRATORY SYNDROME CORONAVIRUS; ENDOTHELIAL GLYCOCALYX DAMAGE; SARS-COV; SPIKE PROTEIN; MERS-COV; THERAPEUTIC-EFFICACY; FUNCTIONAL RECEPTOR; HOST; INFLAMMATION;
D O I
10.1002/ardp.202400307
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Coronavirus disease 2019 (COVID-19) the most contagious infection caused by the unique type of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), produced a global pandemic that wreaked havoc on the health-care system, resulting in high morbidity and mortality. Several methods were implemented to tackle the virus, including the repurposing of existing medications and the development of vaccinations. The purpose of this article is to provide a complete summary of the current state and future possibilities for COVID-19 therapies. We describe the many treatment classes, such as antivirals, immunomodulators, and monoclonal antibodies, that have been repurposed or developed to treat COVID-19. We also looked at the clinical evidence for these treatments, including findings from observational studies and randomized-controlled clinical trials, and highlighted the problems and limitations of the available evidence. Furthermore, we reviewed existing clinical trials and prospective COVID-19 therapeutic options, such as novel medication candidates and combination therapies. Finally, we discussed the long-term consequences of COVID-19 and the importance of ongoing research into the development of viable treatments. This review will help physicians, researchers, and policymakers to understand the prevention and mitigation of COVID-19.
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页数:23
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