Coronavirus disease 2019 (COVID-19) the most contagious infection caused by the unique type of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), produced a global pandemic that wreaked havoc on the health-care system, resulting in high morbidity and mortality. Several methods were implemented to tackle the virus, including the repurposing of existing medications and the development of vaccinations. The purpose of this article is to provide a complete summary of the current state and future possibilities for COVID-19 therapies. We describe the many treatment classes, such as antivirals, immunomodulators, and monoclonal antibodies, that have been repurposed or developed to treat COVID-19. We also looked at the clinical evidence for these treatments, including findings from observational studies and randomized-controlled clinical trials, and highlighted the problems and limitations of the available evidence. Furthermore, we reviewed existing clinical trials and prospective COVID-19 therapeutic options, such as novel medication candidates and combination therapies. Finally, we discussed the long-term consequences of COVID-19 and the importance of ongoing research into the development of viable treatments. This review will help physicians, researchers, and policymakers to understand the prevention and mitigation of COVID-19.
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Kerala Univ Hlth Sci, Dept Pharm, Trichur, Kerala, IndiaKerala Univ Hlth Sci, Dept Pharm, Trichur, Kerala, India
Kumar, Rajesh
Harilal, Seetha
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Kerala Univ Hlth Sci, Dept Pharm, Trichur, Kerala, IndiaKerala Univ Hlth Sci, Dept Pharm, Trichur, Kerala, India
Harilal, Seetha
Al-Sehemi, Abdullah G. G.
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King Khalid Univ, Res Ctr Adv Mat Sci, Abha 61413, Saudi Arabia
King Khalid Univ, Dept Chem, Abha 61413, Saudi ArabiaKerala Univ Hlth Sci, Dept Pharm, Trichur, Kerala, India
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Assoc REMEDES, Ville Sur Jarnioux, FranceAssoc REMEDES, Ville Sur Jarnioux, France
Wiernsperger, Nicolas
Al-Salameh, Abdallah
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Amiens Univ Hosp, Dept Endocrinol Diabet Mellitus & Nutr, Amiens, France
Univ Picardie Jules Verne, PeriTox UMR I 01, Amiens, FranceAssoc REMEDES, Ville Sur Jarnioux, France
Al-Salameh, Abdallah
Cariou, Bertrand
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Univ Nantes, Hop Guillaume & Rene Laennec, Dept Endocrinol Diabetol & Nutr, Inserm,CNRS,Inst Thorax,CHU Nantes, F-44093 Nantes 01, FranceAssoc REMEDES, Ville Sur Jarnioux, France
Cariou, Bertrand
Lalau, Jean-Daniel
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Amiens Univ Hosp, Dept Endocrinol Diabet Mellitus & Nutr, Amiens, France
Univ Picardie Jules Verne, PeriTox UMR I 01, Amiens, FranceAssoc REMEDES, Ville Sur Jarnioux, France
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Multimedia Univ, Fac Business, Melaka 75450, MalaysiaMultimedia Univ, Fac Business, Melaka 75450, Malaysia
Nathan, Robert Jeyakumar
Setiawan, Budi
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Univ Indo Global Mandiri, Fac Econ, Palembang 30129, Indonesia
Hungarian Univ Agr & Life Sci, Doctoral Sch Econ & Reg Sci, H-2100 Godollo, HungaryMultimedia Univ, Fac Business, Melaka 75450, Malaysia
Setiawan, Budi
Mac Nhu Quynh
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Vietnam Chamber Commerce & Ind, Dept Planning & Gen Affairs, Hanoi 10000, VietnamMultimedia Univ, Fac Business, Melaka 75450, Malaysia