Individual Difference in the Capacity of Gut Microbiota to Ferment Four Complex Carbohydrates from Normal to Overweight People: An In Vitro Study

被引：1

作者：

Yu, Chengxiao ^{[1
]}

Ahmadi, Shokouh ^{[1
]}

Hu, Xinxin ^{[1
]}

Wu, Jiaxiong ^{[1
]}

Wu, Dongmei ^{[1
]}

Hou, Zhiqiang ^{[1
]}

Pan, Haibo ^{[1
,4
]}

Xiao, Hang ^{[1
]}

Ye, Xingqian ^{[1
,2
,3
,4
]}

Chen, Shiguo ^{[1
,2
,3
,4
]}

机构：

[1] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Natl Local Joint Engn Lab Intelligent Food Technol, Zhejiang Key Lab Agro Food Proc,Fuli Inst Food Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Zhongyuan Inst, Zhengzhou 450000, Peoples R China

[3] Zhejiang Univ, Shandong Linyi Inst Modern Agr, Linyi 276000, Peoples R China

[4] Zhejiang Univ, Innovat Ctr Yangtze River Delta, Jiaxing 314102, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2024年 / 72卷 / 37期

基金：

中国国家自然科学基金;

关键词：

pectic polysaccharide; fermentation; prebiotic; overweight; microbiota; DIETARY FIBER; OBESITY;

D O I：

10.1021/acs.jafc.4c05864

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Pectic polysaccharides can beneficially shape the human microbiota. However, individual variability in the microbial response, especially the response between normal-weight (NW) and overweight (OW) people, is rarely understood. Therefore, we performed batch fermentation using inulin (INU), commercial pectin (CP), and pectic polysaccharides extracted from goji berry (GPP) and raspberry (RPP) by microbiota from five normal-weight (NW) and five overweight (OW) donors. The degree of specificity of fiber was negatively correlated to its fermentable rate and microbial response. Meanwhile, we found that microbiota from OW donors had a stronger fiber-degrading capacity than NW donors. The result of correlation between individual basal microbiota and the fermentable rate indicated Dialister, Megamonas, Oscillospiraceae_NK4A214, Prevotella, Ruminococcus, and unidentified_Muribaculaceae may be the key bacteria. In summary, we highlighted a new perspective regarding the interactive relationship between different fibers and fecal microbiota from different donors that may be helpful to design fiber interventions for individuals with different microbiota.

引用

页码：20513 / 20526

页数：14