Degraded sweet corn cob polysaccharides modulate T2DM-induced abnormalities in hepatic lipid metabolism via the bile acid-related FXR-SHP and FXR-FGF15-FGFR4 pathways

被引：2

作者：

Xiu, Weiye ^{[1
]}

Wang, Xin ^{[1
]}

Na, Zhiguo ^{[1
]}

Yu, Shiyou ^{[1
]}

Li, Chenchen ^{[1
]}

Wang, Jingyang ^{[1
]}

Yang, Mengyuan ^{[1
]}

Yang, Chenxi ^{[1
]}

Ma, Yongqiang ^{[1
]}

机构：

[1] Harbin Univ Commerce, Coll Food Engn, Heilongjiang Prov Key Lab Cereals & Comprehens Pro, Harbin 150028, Heilongjiang, Peoples R China

来源：

FOOD BIOSCIENCE | 2024年 / 62卷

关键词：

Bile acid synthesis and transportation; Hepatic lipid metabolism; Non-targeted metabolomics; Plant polysaccharides; Type II diabetes mellitus (T2DM); LIVER-INJURY; MICE;

D O I：

10.1016/j.fbio.2024.105085

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by dysregulation of glucose and lipid metabolism. This study aimed to elucidate the mechanism through which a degraded sweet corn cob polysaccharide (UE-DSCCP-A) mitigates T2DM by modulating hepatic lipid metabolism. Biochemical indices pertinent to lipid metabolism were assessed, and liver pathology was examined in T2DM mice following UE-DSCCP-A treatment. Additionally, metabolomics, PCR, and Western blot analyses were employed to investigate the underlying mechanisms involved. These findings indicated that UE-DSCCP-A ameliorated hepatic lipid metabolism disorders, decreased lipid accumulation, and mitigated hepatic fibrosis. Untargeted metabolomics analysis revealed that UE-DSCCP-A modulated pathways associated with steroid biosynthesis and bile acid synthesis and metabolism in T2DM mice. The bile acid assay results demonstrated that UE-DSCCP-A treatment reduced bile acid levels in both the serum and liver but increased fecal bile acid levels in T2DM mice. Furthermore, alterations in bile acid distribution within the liver were observed. UE-DSCCP-A has the capacity to activate the hepatic FXRSHP pathway as well as the gut-liver axis involving FXR-FGF15-FGFR4 signaling. Consequently, UE-DSCCP-A is capable of modulating critical target genes and proteins associated with bile acid synthesis and metabolism, regulating steroid biosynthesis, and influencing bile acid synthesis and transport within the liver. Additionally, it has beneficial effects on lipid metabolism disorders in individuals with T2DM. Thus, UE-DSCCP-A represents a promising candidate for functional foods with inherent hypoglycemic properties.

引用

页数：11