Mutational Analysis of the Binding of Alternative Substrates and Inhibitors to the Active Site of Human Glutathione Transferase P1-1. (vol 8, 1232, 2020)

被引:0
|
作者
Shokeer, Abeer [1 ]
Ismail, Aram [2 ]
Hegazy, Usama M. [1 ]
Kolm, Rudiger H. [2 ]
Mannervik, Bengt [2 ]
机构
[1] Natl Res Ctr, Dept Mol Biol, Genet Engn & Biotechnol Res Div, Giza 12622, Egypt
[2] Stockholm Univ, Dept Biochem & Biophys, Stockholm 10691, Sweden
关键词
D O I
10.3390/pr12071343
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [1] Mutational Analysis of the Binding of Alternative Substrates and Inhibitors to the Active Site of Human Glutathione Transferase P1-1
    Shokeer, Abeer
    Ismail, Aram
    Hegazy, Usama M.
    Kolm, Rudiger H.
    Mannervik, Bengt
    PROCESSES, 2020, 8 (10) : 1 - 12
  • [2] SYNTHESIS OF GLUTATHIONE ANALOGUES AND SCREENING AS SUBSTRATES & INHIBITORS FOR HUMAN GLUTATHIONE TRANSFERASE P1-1
    Pappa, E. V.
    Zompra, A. A.
    Georgakis, N.
    Pairas, G.
    Lamari, F.
    Tsoungas, P.
    Labrou, N.
    Clonis, Y.
    Cordopatis, P.
    JOURNAL OF PEPTIDE SCIENCE, 2014, 20 : S160 - S160
  • [3] Glutathione Analogues as Substrates or Inhibitors That Discriminate between Allozymes of the MDR-Involved Human Glutathione Transferase P1-1
    Zompra, Aikaterini
    Georgakis, Nikolaos
    Pappa, Eleni
    Thireou, Trias
    Eliopoulos, Elias
    Labrou, Nikolaos
    Cordopatis, Paul
    Clonis, Yannis
    BIOPOLYMERS, 2016, 106 (03) : 330 - 344
  • [4] Exit of products from the active site of human glutathione transferase P1-1 is promoted by valine 10
    Micaloni, C
    Mazzetti, AP
    Nuccetelli, M
    Rossjohn, J
    McKinstry, WJ
    Antonini, G
    Caccuri, AM
    Oakley, AJ
    Federici, G
    Ricci, G
    Parker, MW
    Lo Bello, M
    CHEMICO-BIOLOGICAL INTERACTIONS, 2001, 133 (1-3) : 192 - 195
  • [5] PHOTOAFFINITY-LABELING OF THE ACTIVE-SITE OF THE RAT GLUTATHIONE TRANSFERASE-3-3 AND TRANSFERASE-1-1 AND HUMAN GLUTATHIONE TRANSFERASE A1-1
    COOKE, RJ
    BJORNESTEDT, R
    DOUGLAS, KT
    MCKIE, JH
    KING, MD
    COLES, B
    KETTERER, B
    MANNERVIK, B
    BIOCHEMICAL JOURNAL, 1994, 302 : 383 - 390
  • [6] CONTRIBUTION OF 5 AMINO-ACID-RESIDUES IN THE GLUTATHIONE-BINDING SITE TO THE FUNCTION OF HUMAN GLUTATHIONE TRANSFERASE P1-1
    WIDERSTEIN, M
    KOLM, RH
    BJORNESTEDT, R
    MANNERVIK, B
    BIOCHEMICAL JOURNAL, 1992, 285 : 377 - 381
  • [7] The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution
    Oakley, AJ
    LoBello, M
    Battistoni, A
    Ricci, G
    Rossjohn, J
    Villar, HO
    Parker, MW
    JOURNAL OF MOLECULAR BIOLOGY, 1997, 274 (01) : 84 - 100
  • [8] Analysis of the role of the active site tyrosine in human glutathione transferase A1-1 by unnatural amino acid mutagenesis
    Thorson, JS
    Shin, I
    Chapman, E
    Stenberg, G
    Mannervik, B
    Schultz, PG
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (02) : 451 - 452
  • [9] Proton release upon glutathione binding to glutathione transferase P1-1: Kinetic analysis of a multistep glutathione binding process
    Caccuri, AM
    Lo Bello, M
    Nuccetelli, M
    Nicotra, M
    Rossi, P
    Antonini, G
    Federici, G
    Ricci, G
    BIOCHEMISTRY, 1998, 37 (09) : 3028 - 3034
  • [10] Functional studies of tyrosine 108 residue in the active site of human glutathione S-transferase P1-1
    Park, HJ
    Koh, JU
    Ahn, SY
    Kong, KH
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2005, 26 (03): : 433 - 439