Pathophysiology of Peritoneal Metastasis

被引:0
|
作者
Demuytere, Jesse [1 ,2 ]
Ernst, Sam [1 ,2 ,3 ]
Ceelen, Wim [1 ,2 ]
机构
[1] Univ Ghent, Expt Surg Lab, Ghent, Belgium
[2] Canc Res Inst Ghent CRIG, Ghent, Belgium
[3] Univ Ghent, Lab Expt Canc Res LECR, Ghent, Belgium
关键词
metastasis; pathophysiology; peritoneal; INTERSTITIAL FLUID PRESSURE; HUMAN MESOTHELIAL CELLS; ADHESION MOLECULES; ALPHA-V-BETA-3; INTEGRINS; SOLID TUMORS; EXPRESSION; PNEUMOPERITONEUM; MICROENVIRONMENT; MIGRATION; CYTOKINES;
D O I
10.1002/jso.27890
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Peritoneal metastasis is the result of a complex, stepwise process that involves multiple, spatially and temporally distinct interactions between the primary cancer, disseminated cancer cells or clusters, and the mesothelial lining of the peritoneal cavity and intraperitoneal organs. The biology of peritoneal metastasis, long a neglected field of research, is now increasingly being unraveled. Here, we provide an update on the mechanisms that drive the journey that eventually leads to widespread peritoneal metastatic disease.
引用
收藏
页码:1299 / 1305
页数:7
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