Homologous recombination repair (HRR) deficiency in biliary tract cancers: Clinical implications in subsequent therapy lines and correlation with platinum sensitivity

被引：0

作者：

Mavroeidi, I. ^{[1
]}

Mohammad, T. W. Seyed ^{[2
]}

Webersinke, G. ^{[3
]}

Burghofer, J. ^{[4
]}

Piringer, G. ^{[5
]}

Kasper-Virchow, S. ^{[6
]}

Liffers, S-T. ^{[7
]}

Reichinger, A. ^{[8
]}

Kirchweger, P. ^{[9
]}

Heibl, S. ^{[10
]}

Hamacher, R. W. ^{[11
]}

Petzer, A. L. ^{[12
]}

Schuler, M. H. H. ^{[13
]}

Prager, G. ^{[14
]}

Kersting, D. M. ^{[15
]}

Treckmann, J. W. ^{[16
]}

Schildhaus, H-U. ^{[17
]}

Rumpold, H. ^{[18
]}

Siveke, J. T. ^{[19
]}

Doleschal, B. ^{[20
]}

机构：

[1] WTZ Westdeutsches Tumorzentrum Essen, Westdeutsches Tumorzentrum, Essen, Germany

[2] Uniklin St Polten, Dept Internal Med, St Polten, Austria

[3] Ordensklinikum Linz Barmherzige Schwestern, Seilerstatte 4, Linz, Austria

[4] Ordensklinikum Linz GmbH Barmherzige Schwestern, LMGD, Linz, Austria

[5] Johannes Kepler Univ Linz, Kepler Univ Hosp, Dept Med Oncol, Linz, Austria

[6] WTZ Westdeutsches Tumorzentrum Essen, Dept Med Oncol, Essen, Germany

[7] Univ Hosp Essen, Bridge Inst Expt Tumor Therapy, West German Canc Ctr, Essen, Germany

[8] Ordensklinikum Linz Barmherzige Schwestern, Dept Internal Med Hematol Stem Cell Transplatat H, Linz, Austria

[9] Ordensklinikum Linz GmbH Barmherzige Schwestern, Gastrointestinal Canc Ctr, Linz, Austria

[10] Klinikum Wels Grieskirchen GmbH, Abt Innere Med 4, Wels, Austria

[11] Univ Hosp Essen West Deutsch Tumorzentrum, Dept Med Oncol, Essen, Germany

[12] Ordensklinikum Linz GmbH Barmherzige Schwestern, Hematol Stem Cell Transplantat & Med Oncol, Linz, Austria

[13] Univ Essen Gesamthsch, Dept Med Oncol, Essen, Germany

[14] Univ Kliniken MedUni Wien, Dept Med, AKH Wien, Vienna, Austria

[15] Univ Essen Gesamthsch, Dept Nucl Med, Essen, Germany

[16] Univ Hosp Essen, Dept Surg & Transplantat, Essen, Germany

[17] Univ Hosp Essen, Inst Pathol, Essen, Germany

[18] Ordensklinikum Linz GmbH Barmherzige Schwestern, Visceral Canc Ctr, Linz, Austria

[19] Univ Klinikum Essen, Bridge Inst Expt Tumor Therapy, Essen, Germany

[20] Ordensklinikum Linz GmbH Barmherzige Schwestern, Dept Haematol & Oncol, Linz, Austria

来源：

ANNALS OF ONCOLOGY | 2024年 / 35卷

关键词：

D O I：

10.1016/j.annonc.2024.05.308

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

301P

引用

页码：S127 / S127

页数：1

共 13 条

[1] Understanding homologous recombination repair deficiency in biliary tract cancers: clinical implications and correlation with platinum sensitivity
Mavroeidi, I. A.
Burghofer, J.
Kalbourtzis, S.
Taghizadeh, H.
Webersinke, G.
Piringer, G.
Kasper, S.
Schreil, G.
Liffers, S. T.
Reichinger, A.
Kirchweger, P.
Heibl, S.
Hamacher, R.
Schmitt, C. A.
Schuler, M.
Prager, G. W.
Kersting, D.
Treckmann, J.
Schildhaus, H. -U
Rumpold, H.
Siveke, J. T.
Doleschal, B.
[J]. ESMO OPEN, 2024, 9 (08)
[2] Deleterious alterations in homologous recombination repair genes and efficacy of platinum-based chemotherapy in biliary tract cancers
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[3] Homologous Recombination Repair in Biliary Tract Cancers: A Prime Target for PARP Inhibition?
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[6] Clinical and Genetic Implications of DNA Mismatch Repair Deficiency in Biliary Tract Cancers Associated with Lynch Syndrome
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[8] Impact of homologous recombination repair (HRR) or nucleotide excision repair (NER) deficiency on sensitivity to antibody drug conjugate (ADC) payloads in urothelial cancer.
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[J]. JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (4_SUPPL) : 665 - 665
[9] Analytical and clinical validation of a ctDNA assay for detecting copy number loss and structural rearrangement variants contributing to homologous recombination and repair (HRR) deficiency
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[10] Effect of genomic loss of heterozygosity and homologous recombination deficiency on platinum sensitivity and clinical course in women with epithelial ovarian cancer
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