Cancer cell - Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma

被引：0

作者：

Giangreco, Giovanni ^{[1
]}

Rullan, Antonio

Naito, Yutaka ^{[9
]}

Biswas, Dhruva ^{[4
,5
,6
]}

Liu, Yun-Hsin ^{[7
]}

Hooper, Steven ^{[1
]}

Nenclares, Pablo ^{[2
]}

Bhide, Shreerang ^{[2
]}

Cheang, Maggie Chon U.

Chakravarty, Probir

Hirata, Eishu ^{[1
,10
]}

Swanton, Charles ^{[5
,6
,8
]}

Melcher, Alan

Harrington, Kevin ^{[2
,3
]}

Sahai, Erik ^{[1
]}

机构：

[1] Francis Crick Inst, Tumour Cell Biol Lab, 1 Midland Rd, London NW1 1AT, England

[2] Inst Canc Res, Dept Radiotherapy & Imaging, 237 Fulham Rd, London SW3 6JB, England

[3] Royal Marsden Hosp, Head & Neck Unit, 203 Fulham Rd, London SW3 6JJ, England

[4] UCL, Canc Inst, Canc Res UK Lung Canc Ctr Excellence, 72 Huntley St, London WC1E 6DD, England

[5] Francis Crick Inst, Canc Evolut & Genome Instabil Lab, 1 Midland Rd, London NW1 1AT, England

[6] UCL, Canc Inst, Bill Lyons Informat Ctr, 72 Huntley St, London WC1E 6DD, England

[7] Francis Crick Inst, Bioinformat Platform, 1 Midland Rd, London NW1 1AT, England

[8] Univ Coll London Hosp, Dept Oncol, London, England

[9] Nippon Med Sch, Inst Adv Med Sci, Dept Bioregulat, Tokyo, Japan

[10] Kanazawa Univ, Div Tumor Cell Biol & Bioimaging, Canc Res Inst, Kanazawa, Japan

来源：

ISCIENCE | 2024年 / 27卷 / 09期

关键词：

HUMAN-PAPILLOMAVIRUS; LUNG-CANCER; HEAD; ACTIVATION; SURVIVAL;

D O I：

10.1016/j.isci.2024.110635

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interactions between cells in the tumor microenvironment (TME) shape cancer progression and patient prognosis. To gain insights into how the TME influences cancer outcomes, we derive gene expression signatures indicative of signaling between stromal fibroblasts and cancer cells, and demonstrate their prognostic significance in multiple and independent squamous cell carcinoma cohorts. By leveraging information within the signatures, we discover that the HB-EGF/EGFR/MAPK axis represents a hub of tumorstroma crosstalk, promoting the expression of CSF2 and LIF and favoring the recruitment of macrophages. Together, these analyses demonstrate the utility of our approach for interrogating the extent and consequences of TME crosstalk.

引用

页数：24

共 44 条

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