RNA modifications in long non-coding RNAs and their implications in cancer biology

被引：2
|
作者：
Li, Jiexin [1 ,2 ]
Wang, Xiansong [1 ,2 ]
Wang, Hongsheng [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Peoples R China
[2] Sun Yat Sen Univ, Sch Pharmaceut Sci, State Key Lab Antiinfect Drug Discovery & Dev, Guangzhou 510006, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2024年 / 113卷
基金：
中国国家自然科学基金;
关键词：
lncRNA; RNA modification; Methylation; Pseudouracil modification; Cancer; MESSENGER-RNA; MAPPING REVEALS; METHYLATION PROMOTES; LUNG ADENOCARCINOMA; M(6)A MODIFICATION; LNCRNA SIGNATURE; CELL; PSEUDOURIDYLATION; PROLIFERATION; WIDESPREAD;
D O I：
10.1016/j.bmc.2024.117922
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long non-coding RNAs (lncRNAs) represent the most diverse class of RNAs in cells and play crucial roles in maintaining cellular functions. RNA modifications, being a significant factor in regulating RNA biology, have been found to be extensively present in lncRNAs and exert regulatory effects on their behavior and biological functions. Most common types of RNA modifications in lncRNAs include N6-methyladenosine (m(6)A), 5-methylcytosine (m(5)C), and N1-methyladenosine (m(1)A). In this review, we summarize the major RNA modification types associated with lncRNAs, the regulatory roles of each modification, and the implications of modified lncRNAs in tumorigenesis and development. By examining these aspects, we aim to provide insights into the role of RNA modifications in lncRNAs and their potential impact on cancer biology.
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页数：8
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