Factors Determining Epithelial-Mesenchymal Transition in Cancer Progression

被引:1
|
作者
Tomecka, Paulina [1 ]
Kunachowicz, Dominika [2 ]
Gorczynska, Julia [1 ]
Gebuza, Michal [1 ]
Kuznicki, Jacek [1 ]
Skinderowicz, Katarzyna [1 ]
Choromanska, Anna [3 ]
机构
[1] Wroclaw Med Univ, Fac Med, PL-50367 Wroclaw, Poland
[2] Wroclaw Med Univ, Fac Pharm, Dept Pharmaceut Biochem, Borowska 211a, PL-50556 Wroclaw, Poland
[3] Wroclaw Med Univ, Fac Pharm, Dept Mol & Cellular Biol, Borowska 211a, Wroclaw, Poland
关键词
epithelial-mesenchymal transition; cancer; tumor microenvironment; cellular plasticity; regulatory factors; EPIDERMAL-GROWTH-FACTOR; CIRCULATING TUMOR-CELLS; NF-KAPPA-B; BREAST-CANCER; PROSTATE-CANCER; UP-REGULATION; STEM-CELLS; E-CADHERIN; HEPATOCELLULAR-CARCINOMA; EXTRACELLULAR-MATRIX;
D O I
10.3390/ijms25168972
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epithelial-mesenchymal transition (EMT) is a process in which an epithelial cell undergoes multiple modifications, acquiring both morphological and functional characteristics of a mesenchymal cell. This dynamic process is initiated by various inducing signals that activate numerous signaling pathways, leading to the stimulation of transcription factors. EMT plays a significant role in cancer progression, such as metastasis and tumor heterogeneity, as well as in drug resistance. In this article, we studied molecular mechanisms, epigenetic regulation, and cellular plasticity of EMT, as well as microenvironmental factors influencing this process. We included both in vivo and in vitro models in EMT investigation and clinical implications of EMT, such as the use of EMT in curing oncological patients and targeting its use in therapies. Additionally, this review concludes with future directions and challenges in the wide field of EMT.
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页数:47
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