TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models

被引：0

作者：

Hackett, Christopher S. ^{[1
,2
,3
,4
]}

Hirschhorn, Daniel ^{[1
,2
,3
,4
]}

Tang, Meixian S. ^{[2
,3
,4
]}

Purdon, Terence J. ^{[5
]}

Marouf, Yacine ^{[2
,3
,4
]}

Piersigilli, Alessandra ^{[6
,11
]}

Agaram, Narasimhan P. ^{[7
]}

Liu, Cailian ^{[2
,3
,4
]}

Schad, Sara E. ^{[2
,3
,4
,9
,10
]}

de Stanchina, Elisa ^{[8
]}

Rafiq, Sarwish

Monette, Sebastien ^{[6
]}

Wolchok, Jedd D. ^{[1
,2
,3
,4
,12
]}

Merghoub, Taha ^{[1
,2
,3
,4
]}

Brentjens, Renier J. ^{[1
,5
]}

机构：

[1] Weill Cornell Med, Dept Med, New York, NY 10065 USA

[2] Weill Cornell Med, Dept Pharmacol, Swim Amer & Ludwig Collaborat Lab, New York, NY 10065 USA

[3] Weill Cornell Med, Parker Inst Canc Immunotherapy, New York, NY 10065 USA

[4] Weill Cornell Med, Sandra & Edward Meyer Canc Ctr, New York, NY 10065 USA

[5] Roswell Park Comprehens Canc Ctr, Buffalo, NY 14203 USA

[6] Rockefeller Univ, Mem Sloan Kettering Canc Ctr, Lab Comparat Pathol, Weill Cornell Med, New York, NY 10065 USA

[7] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA

[8] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA

[9] Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA

[10] Winship Canc Inst, Atlanta, GA 30322 USA

[11] Takeda Dev Ctr Amer Inc, Drug Safety Res & Evaluat, Cambridge, MA 02139 USA

[12] Weill Cornell Med, Parker Inst Canc Immunotherapy & Sandra, Dept Med, Swim Amer & Ludwig Collaborat Lab,Edward Meyer Can, New York, NY 10065 USA

来源：

MOLECULAR THERAPY ONCOLOGY | 2024年 / 32卷 / 03期

关键词：

CLINICAL-EFFICACY; ADOPTIVE TRANSFER; SOLID TUMORS; ANTIGEN; DIFFERENTIATION; EXPRESSION; MELANOCYTES; MANAGEMENT; RESISTANCE; NIVOLUMAB;

D O I：

10.1016/j.omton.2024.200862

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite therapeutic efficacy observed with immune checkpoint blockade in advanced melanoma, many tumors do not respond to treatment, representing a need for new therapies. Here, we have generated chimeric antigen receptor (CAR) T cells targeting TYRP1, a melanoma differentiation antigen expressed on the surface of melanomas, including rare acral and uveal melanomas. TYRP1-targeted CART cells demonstrate antigen-specific activation and cytotoxic activity in vitro and in vivo against human melanomas independent of the MHC alleles and expression. In addition, the toxicity to pigmented normal tissues observed with T lymphocytes expressing TYRP1-targeted TCRs was not observed with TYRP1-targeted CAR T cells. Anti-TYRP1 CAR T cells provide a novel means to target advanced melanomas, serving as a platform for the development of similar novel therapeutic agents and as a tool to interrogate the immunobiology of melanomas.

引用

页数：12

共 50 条

[1] TYRP1, a missing link between melanogenesis and melanoma progression?
Ghanem, G.
Journe, F.
Mogha, A.
Van Kempen, L.
Galibert, M. -D.
[J]. PIGMENT CELL & MELANOMA RESEARCH, 2011, 24 (04) : 775 - 775
[2] CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes
Jilani, Sameeha
Saco, Justin D.
Mugarza, Edurne
Pujol-Morcillo, Aleida
Chokry, Jeffrey
Ng, Clement
Abril-Rodriguez, Gabriel
Berger-Manerio, David
Pant, Ami
Hu, Jane
Gupta, Rubi
Vega-Crespo, Agustin
Baselga-Carretero, Ignacio
Chen, Jia M.
Shin, Daniel Sanghoon
Scumpia, Philip
Radu, Roxana A.
Chen, Yvonne
Ribas, Antoni
Puig-Saus, Cristina
[J]. NATURE COMMUNICATIONS, 2024, 15 (01)
[3] CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes
Sameeha Jilani
Justin D. Saco
Edurne Mugarza
Aleida Pujol-Morcillo
Jeffrey Chokry
Clement Ng
Gabriel Abril-Rodriguez
David Berger-Manerio
Ami Pant
Jane Hu
Rubi Gupta
Agustin Vega-Crespo
Ignacio Baselga-Carretero
Jia M. Chen
Daniel Sanghoon Shin
Philip Scumpia
Roxana A. Radu
Yvonne Chen
Antoni Ribas
Cristina Puig-Saus
[J]. Nature Communications, 15
[4] To explore the relationship of tyrp1 gene and melanoma tumor growth by piggyBac transposon mutagenesis
Hong, J.
Huang, Y.
Liao, Y.
Chu, C.
Chen, Y.
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2013, 133 : S237 - S237
[5] Uncovered role of Tyrosinase-related Protein 1 TYRP1 in melanoma cells aggressiveness
Mogha, A.
Gilot, D.
Primot, A.
Debbache, J.
Journe, F.
Bennett, D. C.
Dreno, B.
Napolitano, A.
Ghanem, G.
Galibert, M. -D.
[J]. PIGMENT CELL & MELANOMA RESEARCH, 2011, 24 (04) : 791 - 791
[6] Differential expression of TYRP1 in adult human retinal pigment epithelium and uveal melanoma cells
Qiu, Chun
Li, Peng
Bi, Jianjun
Wu, Qing
Lu, Linna
Qian, Guanxiang
Jia, Renbing
Jia, Rong
[J]. ONCOLOGY LETTERS, 2016, 11 (04) : 2379 - 2383
[7] TSTEM-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models
Meyran, Deborah
Zhu, Joe Jiang
Butler, Jeanne
Tantalo, Daniela
MacDonald, Sean
Nguyen, Thu Ngoc
Wang, Minyu
Thio, Niko
D'Souza, Criselle
Qin, Vicky Mengfei
Slaney, Clare
Harrison, Aaron
Sek, Kevin
Petrone, Pasquale
Thia, Kevin
Giuffrida, Lauren
Scott, Andrew M.
Terry, Rachael L.
Tran, Ben
Desai, Jayesh
Prince, H. Miles
Harrison, Simon J.
Beavis, Paul A.
Kershaw, Michael H.
Solomon, Ben
Ekert, Paul G.
Trapani, Joseph A.
Darcy, Phillip K.
Neeson, Paul J.
[J]. SCIENCE TRANSLATIONAL MEDICINE, 2023, 15 (690)
[8] Enhancing Tumor Directed T Cells with a Costimulatory CAR
Cardenas, Mara G.
Daum, Rachel
Rooney, Cliona M.
Arber, Caroline
Omer, Bilal
[J]. MOLECULAR THERAPY, 2020, 28 (04) : 211 - 211
[9] TYRP2-mediated resistance to cis-diamminedichloroplatinum (II) in human melanoma cells is independent of tyrosinase and TYRP1 expression and melanin content
Pak, BJ
Li, Q
Kerbel, RS
Ben-David, Y
[J]. MELANOMA RESEARCH, 2000, 10 (05) : 499 - 505
[10] CAR-T cell therapy for melanoma targeting surface expression of TYRP-1.
Saus, Cristina Puig
Jilani, Sameeha
Saco, Justin
Ng, Clement
Coffman, Jane
Radu, Roxana
Chen, Yvonne
Ribas, Antoni
[J]. CANCER RESEARCH, 2021, 81 (13)

← 1 2 3 4 5 →