Cutaneous Melanoma: An Overview of Physiological and Therapeutic Aspects and Biotechnological Use of Serine Protease Inhibitors

被引:0
|
作者
Boleti, Ana Paula De Araujo [1 ]
Jacobowski, Ana Cristina [1 ]
Monteiro-Alfredo, Tamaeh [1 ]
Pereira, Ana Paula Ramos [1 ]
Oliva, Maria Luiza Vilela [2 ]
Maria, Durvanei Augusto [3 ]
Macedo, Maria Ligia Rodrigues [1 ,4 ]
机构
[1] Fed Univ Mato Grosso Sul UFMS, Food Technol & Publ Hlth Unit, Lab Prot Purificat & Their Biol Funct, BR-79070900 Campo Grande, MS, Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Bioquim, BR-04023062 Sao Paulo, SP, Brazil
[3] Inst Butantan, Serv Bioquim, Div Ciencias Fisiol & Quim, BR-05585000 Sao Paulo, SP, Brazil
[4] Univ Fed Mato Grosso do Sul, Dept Pharmaceut Sci Food & Nutr, BR-79070900 Campo Grande, MS, Brazil
来源
MOLECULES | 2024年 / 29卷 / 16期
关键词
skin cancer; etiology; staging; targeted therapy; proteolytic activity; PLANT PROTEINASE-INHIBITOR; LENTIGO MALIGNA MELANOMA; DESMOPLASTIC MELANOMA; ENTEROLOBIUM-CONTORTISILIQUUM; INTRATUMORAL INJECTION; METASTATIC MELANOMA; MELANOCYTIC NEVI; ACRAL MELANOMA; GENE-THERAPY; DOUBLE-BLIND;
D O I
10.3390/molecules29163891
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Metastatic melanoma stands out as the most lethal form of skin cancer because of its high propensity to spread and its remarkable resistance to treatment methods. Methods: In this review article, we address the incidence of melanoma worldwide and its staging phases. We thoroughly investigate the different melanomas and their associated risk factors. In addition, we underscore the principal therapeutic goals and pharmacological methods that are currently used in the treatment of melanoma. Results: The implementation of targeted therapies has contributed to improving the approach to patients. However, because of the emergence of resistance early in treatment, overall survival and progression-free periods continue to be limited. Conclusions: We provide new insights into plant serine protease inhibitor therapeutics, supporting high-throughput drug screening soon, and seeking a complementary approach to explain crucial mechanisms associated with melanoma.
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页数:28
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