Management of patients with extensive small-cell lung cancer in the immunotherapy era: An Italian consensus through a Delphi approach

被引：1

作者：

Ceresoli, Giovanni Luca

Rossi, Giulio ^{[1
]}

Agustoni, Francesco ^{[2
,3
]}

Bonomi, Lucia ^{[4
]}

Borghetti, Paolo ^{[5
]}

Bulotta, Alessandra ^{[6
]}

Casartelli, Clelia ^{[7
]}

Cerea, Giulio ^{[8
]}

Colonese, Francesca ^{[9
]}

del Signore, Ester ^{[10
,11
]}

Finocchiaro, Giovanna ^{[12
]}

Gianoncelli, Letizia ^{[13
]}

Grisanti, Salvatore ^{[14
]}

Maiolani, Martina ^{[15
]}

Pagni, Fabio ^{[16
]}

Proto, Claudia ^{[17
]}

Rijavec, Erika ^{[18
]}

Vittimberga, Isabella ^{[19
]}

Arcangeli, Stefano ^{[20
]}

Filippi, Andrea Riccardo ^{[21
,22
]}

机构：

[1] Human Gavazzeni Hosp, Dept Med Oncol, Bergamo, Italy

[2] Hosp Inst Fdn Poliambulanza, Pathol Unit, Via Bissolati 57, I-25124 Brescia, Italy

[3] Univ Pavia, Dept Internal Med & Med Therapy, Pavia, Italy

[4] Fdn IRCCS Policlin San Matteo, Med Oncol Unit, Pavia, Italy

[5] ASST Papa Giovanni XXIII Hosp, Unit Oncol, Bergamo, Italy

[6] ASST Spedali Civili & Univ Brescia, Radiat Oncol Dept, Brescia, Italy

[7] IRCCS San Raffaele, Dept Oncol, via Olgettina 60, Milan, Italy

[8] Valduce Hosp, Unit Oncol, Como, Italy

[9] ASST Grande Osped Metropolitano Niguarda, Niguarda Canc Ctr, Milan, Italy

[10] ASST San Gerardo Monza, Med Oncol Unit, Monza, Italy

[11] European Inst Oncol, Div Thorac Oncol, IEO, Milan, Italy

[12] IRCCS, Ist Clin Human, Human Canc Ctr, Med Oncol & Hematol Unit, Rozzano, Italy

[13] San Paolo Hosp, Med Oncol Unit, ASST Santi Paolo & Carlo, Milan, Italy

[14] Univ Brescia, ASST Spedali Civili Brescia, Dept Med & Surg Specialties Radiol Sci & Publ Hlth, Med Oncol Unit, Brescia, Italy

[15] UOC Oncol Med ASST Valtellina & Alto Lario, Sondrio, Italy

[16] Univ Milano Bicocca, Dept Med & Surg, Pathol, Via Cadore 48, I-20900 Monza, Italy

[17] Fdn IRCCS Ist Nazl Tumori, Dept Med Oncol, Milan, Italy

[18] ASST Sette Laghi, Osped Circolo & Fdn Macchi, Unit Med Oncol, Varese, Italy

[19] Osped A Manzoni, Oncol Dept, Lecce, Italy

[20] Univ Milano Bicocca, Dept Radiat Oncol, Milan, Italy

[21] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pavia, Italy

[22] Fdn IRCCS Policlin San Matteo, Radiat Oncol, Pavia, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2024年 / 199卷

关键词：

Small-cell lung cancer; SCLC; Immunotherapy; Patient management; PLUS PLATINUM-ETOPOSIDE; ES-SCLC; ATEZOLIZUMAB ATZ; PD-L1; EXPRESSION; CARBOPLATIN CB; PHASE IIIB; OPEN-LABEL; SURVIVAL; DURVALUMAB; SUBTYPES;

D O I：

10.1016/j.critrevonc.2023.104247

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Immunotherapy represented a turning point for treating extensive small-cell lung cancer (ES-SCLC). Although, many issues remain debated. Methods: A group of Italian medical and radiation oncologists with expertise in managing patients with ES-SCLC developed a list of statements divided in six areas of interest. The Delphi method was used to assess the consensus on the defined list of statements. Results: 32 statements were included in the final list to be voted by the Delphi panel, and 26 reached a consensus on the agreement. A prompt involvement of a multidisciplinary team is a priority to provide an integrated treatment strategy. First-line recommended treatment is immunotherapy in combination with platinum-based chemotherapy and etoposide for four cycles followed by maintenance immunotherapy. Conclusions: While awaiting new data from clinical trials and real-world studies, these recommendations can represent a useful tool to guide the management of ES-SCLC patients in daily practice.

引用

页数：9

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