Metabolic Syndrome and Psoriasis: Pivotal Roles of Chronic Inflammation and Gut Microbiota

被引:1
|
作者
Secchiero, Paola [1 ,2 ]
Rimondi, Erika [1 ,2 ]
Marcuzzi, Annalisa [3 ]
Longo, Giovanna [3 ]
Papi, Chiara [3 ]
Manfredini, Marta [3 ]
Fields, Matteo [3 ]
Caruso, Lorenzo [4 ]
Di Caprio, Roberta [5 ]
Balato, Anna [5 ]
机构
[1] Univ Ferrara, Dept Translat Med, I-44121 Ferrara, Italy
[2] Univ Ferrara, LTTA Ctr, I-44121 Ferrara, Italy
[3] Univ Ferrara, Dept Translat Med, I-44121 Ferrara, Italy
[4] Univ Ferrara, Dept Environm & Prevent Sci, I-44121 Ferrara, Italy
[5] Univ Campania Luigi Vanvitelli, Dept Mental & Phys Hlth & Prevent Med, Dermatol Unit, I-80131 Naples, Italy
关键词
metabolic syndrome; inflammation; insulin resistance; adipose tissue; psoriasis; LINKING PSORIASIS; INTERLEUKIN-18; PROTECTS; THERAPY; DISEASE; ADIPOSE; RISK; MICE;
D O I
10.3390/ijms25158098
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In recent years, the incidence of metabolic syndrome (MS) has increased due to lifestyle-related factors in developed countries. MS represents a group of conditions that increase the risk of diabetes, cardiovascular diseases, and other severe health problems. Low-grade chronic inflammation is now considered one of the key aspects of MS and could be defined as a new cardiovascular risk factor. Indeed, an increase in visceral adipose tissue, typical of obesity, contributes to the development of an inflammatory state, which, in turn, induces the production of several proinflammatory cytokines responsible for insulin resistance. Psoriasis is a chronic relapsing inflammatory skin disease and is characterized by the increased release of pro-inflammatory cytokines, which can contribute to different pathological conditions within the spectrum of MS. A link between metabolic disorders and Psoriasis has emerged from evidence indicating that weight loss obtained through healthy diets and exercise was able to improve the clinical course and therapeutic response of Psoriasis in patients with obesity or overweight patients and even prevent its occurrence. A key factor in this balance is the gut microbiota; it is an extremely dynamic system, and this makes its manipulation through diet possible via probiotic, prebiotic, and symbiotic compounds. Given this, the gut microbiota represents an additional therapeutic target that can improve metabolism in different clinical conditions.
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页数:14
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