Synthesis of new bis-heterocyclic hybrids linked by iso-propanol unit via Hantzsch, Michael, and Biginelli reactions

被引：3

作者：

Diab, Hadeer M. ^{[1
]}

Mahmoud, Nesma E. ^{[1
]}

Abdelhamid, Ismail A. ^{[1
]}

Elwahy, Ahmed H. M. ^{[1
]}

Fares, Ibrahim M. Z. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Chem Dept, Giza, Egypt

来源：

ARKIVOC | 2024年

关键词：

Bis(aldehyde) tethered iso-propanol unit; Hantzsch reaction; Michael addition reaction; hybrid molecules; FUSED HETEROCYCLES; DERIVATIVES; PYRIDAZINES; SCAFFOLDS; PYRIDINE; DESIGN; ROUTES;

D O I：

10.24820/ark.5550190.p012.209

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Combining compounds with complementary bioactivities to create hybrid molecules is a new idea in drug research. In this work, we created novel hybrid molecules including bis-heterocycles connected by an isopropanol unit. This is accomplished by the condensation of 4,4'-((2-hydroxypropane-1,3diyl)bis(oxy))dibenzaldehyde with the appropriate reagents using Hantzsch, Michael, and Biginelli reactions. The structures of the newly synthesized compounds are determined by elemental analysis, 1H NMR, 13C NMR, IR, and MS spectra.

引用

页数：14

共 10 条

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