Genetic and Epigenetic Interactions Involved in Senescence of Stem Cells
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作者:
Iordache, Florin
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Univ Agron Sci & Vet Med, Fac Vet Med, Biochem Disciplines, Bucharest 050097, Romania
Politehn Univ, Adv Res Ctr Innovat Mat Prod & Proc CAMPUS, Bucharest 060042, RomaniaUniv Agron Sci & Vet Med, Fac Vet Med, Biochem Disciplines, Bucharest 050097, Romania
Iordache, Florin
[1
,2
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Petcu, Adriana Cornelia Ionescu
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Univ Agron Sci & Vet Med, Fac Vet Med, Biochem Disciplines, Bucharest 050097, RomaniaUniv Agron Sci & Vet Med, Fac Vet Med, Biochem Disciplines, Bucharest 050097, Romania
Petcu, Adriana Cornelia Ionescu
[1
]
Alexandru, Diana Mihaela
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Univ Agron Sci & Vet Med, Fac Vet Med, Pharmacol & Pharm Disciplines, Bucharest 050097, RomaniaUniv Agron Sci & Vet Med, Fac Vet Med, Biochem Disciplines, Bucharest 050097, Romania
Alexandru, Diana Mihaela
[3
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机构:
[1] Univ Agron Sci & Vet Med, Fac Vet Med, Biochem Disciplines, Bucharest 050097, Romania
[2] Politehn Univ, Adv Res Ctr Innovat Mat Prod & Proc CAMPUS, Bucharest 060042, Romania
[3] Univ Agron Sci & Vet Med, Fac Vet Med, Pharmacol & Pharm Disciplines, Bucharest 050097, Romania
Cellular senescence is a permanent condition of cell cycle arrest caused by a progressive shortening of telomeres defined as replicative senescence. Stem cells may also undergo an accelerated senescence response known as premature senescence, distinct from telomere shortening, as a response to different stress agents. Various treatment protocols have been developed based on epigenetic changes in cells throughout senescence, using different drugs and antioxidants, senolytic vaccines, or the reprogramming of somatic senescent cells using Yamanaka factors. Even with all the recent advancements, it is still unknown how different epigenetic modifications interact with genetic profiles and how other factors such as microbiota physiological conditions, psychological states, and diet influence the interaction between genetic and epigenetic pathways. The aim of this review is to highlight the new epigenetic modifications that are involved in stem cell senescence. Here, we review recent senescence-related epigenetic alterations such as DNA methylation, chromatin remodeling, histone modification, RNA modification, and non-coding RNA regulation outlining new possible targets for the therapy of aging-related diseases. The advantages and disadvantages of the animal models used in the study of cellular senescence are also briefly presented.
机构:
Harbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R ChinaHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Wang, X.
Li, S.
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机构:
Univ Leipzig, Dept Cariol Endodontol & Periodontol, Leipzig, GermanyHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Li, S.
Ma, Y.
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机构:
Kumamoto Univ, Dept Neurol, Kumamoto, JapanHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Ma, Y.
Hu, X.
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机构:
Beijing Tibetan Hosp, China Tibetol Res Ctr, Mol Cell Biol Lab, Beijing, Peoples R ChinaHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Hu, X.
Chukwunonso, O.
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机构:
Univ Leipzig, Felix Bloch Inst Solid State Phys, Leipzig, GermanyHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Chukwunonso, O.
Acharya, A.
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机构:
Univ Hong Kong, Fac Dent, Hong Kong, Peoples R ChinaHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Acharya, A.
Haak, R.
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机构:
Univ Leipzig, Dept Cariol Endodontol & Periodontol, Leipzig, GermanyHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Haak, R.
Savkovic, V.
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机构:
Univ Leipzig, Dept Oral & Maxillofacial Plast Surg, Leipzig, GermanyHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Savkovic, V.
Li, H.
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机构:
Univ Leipzig, Dept Oral & Maxillofacial Plast Surg, Leipzig, GermanyHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Li, H.
Gaus, S.
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机构:
Univ Leipzig, Dept Oral & Maxillofacial Plast Surg, Leipzig, GermanyHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Gaus, S.
Ziebolz, D.
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机构:
Univ Leipzig, Dept Cariol Endodontol & Periodontol, Leipzig, GermanyHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Ziebolz, D.
Schmalz, G.
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机构:
Univ Leipzig, Dept Cariol Endodontol & Periodontol, Leipzig, GermanyHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
Schmalz, G.
Su, Z.
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机构:
Harbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R ChinaHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China
机构:
Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Pauwelsstraße 20, Aachen
Institute for Biomedical Engineering–Cell Biology, RWTH Aachen Medical School, AachenHelmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Pauwelsstraße 20, Aachen
Franzen J.
Wagner W.
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机构:
Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Pauwelsstraße 20, Aachen
Institute for Biomedical Engineering–Cell Biology, RWTH Aachen Medical School, AachenHelmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Pauwelsstraße 20, Aachen
Wagner W.
Fernandez-Rebollo E.
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机构:
Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Pauwelsstraße 20, Aachen
Institute for Biomedical Engineering–Cell Biology, RWTH Aachen Medical School, AachenHelmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Pauwelsstraße 20, Aachen