Polymer-Based Nanoparticles for Inner Ear Targeted Trans Differentiation Gene Therapy

被引:0
|
作者
Foster, Thomas [1 ,2 ,3 ]
Lim, Patrick [1 ,2 ]
Jones, Melissa [1 ,2 ,4 ]
Wagle, Susbin Raj [1 ,2 ]
Kovacevic, Bozica [1 ,2 ]
Ionescu, Corina Mihaela [1 ,2 ]
Wong, Elaine Y. M. [4 ]
Mooranian, Armin [1 ,2 ,5 ]
Al-Salami, Hani [1 ,2 ,6 ]
机构
[1] Curtin Univ, Curtin Med Sch, Biotechnol & Drug Dev Res Lab, Bentley, WA 6102, Australia
[2] Curtin Univ, Curtin Hlth Innovat Res Inst, Bentley, WA 6102, Australia
[3] Royal Perth Hosp, Dept Clin Biochem, Pathwest Lab Med, Perth, WA 6000, Australia
[4] Ear Sci Inst Australia, Queen Elizabeth II Med Ctr, Hearing Therapeut Dept, Perth, WA 6009, Australia
[5] Univ Otago, Sch Pharm, Dunedin 9016, Otago, New Zealand
[6] Univ Western Australia, Med Sch, Crawley, WA 6009, Australia
关键词
Hearing-Loss; Stem-cells; Gene-Delivery; Inner Ear; Nanotechnology; Bile Acid; Polymers; HAIR-CELL REGENERATION; INDUCED HEARING-LOSS; BLOOD-BRAIN-BARRIER; DRUG-DELIVERY; SUPPORTING CELLS; DNA NANOPARTICLES; IMPROVES HEARING; AUDITORY NEURONS; SIRNA DELIVERY; PLASMID DNA;
D O I
10.1002/cmdc.202400038
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Hearing loss is a significant disability that often goes under recognised, largely due to poor identification, prevention, and treatment. Steps are being made to amend these pitfalls in the investigation of hearing loss, however, the development of a cure to reverse advanced forms remains distant. This review details some current advances in the treatment of hearing loss, with a particular focus on genetic-based nanotechnology and how it may provide a useful avenue for further research. This review presents a broad background on the pathophysiology of hearing loss and some current interventions. We also highlight some potential genes that may be useful in the amelioration of hearing loss. Pathways of cellular differentiation from stem or supporting cell to functional hair cell are covered in detail, as this mechanism represents a key means of regenerating these cell types. Overall, we believe that polymer-based nanotechnology coupled with novel excipients represents a useful area of further research in the treatment of hearing loss, although further studies in this area are required. Targeted gene delivery, a cutting-edge technology, has potential applications in treating various disorders, including hearing loss. This review focuses on gene therapy in the inner ear, with particular focus on its use in cellular trans differentiation. This review places particular emphasis on the potential of non-viral delivery systems and highlights how they may provide significant benefit in this space. image
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页数:14
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