Mitochondrial Function and Resistance to Oxidative Stress in the Kidney during Pregnancy

被引：0

作者：

Popkov, V. A. ^{[1
,2
]}

Buyan, M. I. ^{[3
]}

Makievskaya, K. I. ^{[2
,3
]}

Brezgunova, A. A. ^{[1
,3
]}

Pevzner, I. B.

Zorova, L. D. ^{[1
]}

Zorov, D. B. ^{[1
]}

Plotnikov, E. Yu. ^{[1
]}

Andrianova, N. V. ^{[1
,2
]}

机构：

[1] Lomonosov Moscow State Univ, AN Belozersky Inst Physicochem Biol, Moscow, Russia

[2] Lomonosov Moscow State Univ, Inst Artificial Intelligence, Moscow, Russia

[3] Lomonosov Moscow State Univ, Fac Bioengn & Bioinformat, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2024年 / 177卷 / 04期

基金：

俄罗斯科学基金会;

关键词：

pregnancy; kidney; mitochondria; reactive oxygen species; ischemia/reperfusion; SYSTEM; INJURY; LIVER;

D O I：

10.1007/s10517-024-06205-w

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We demonstrated that the serum of pregnant rats increases viability of kidney epithelial cells and promotes their proliferation. The intensity of oxidative stress in the kidneys was also reduced during pregnancy, but only in rats that were not exposed to acute ischemic kidney injury. This decrease in oxidative stress was not associated with changes in transmembrane mitochondrial potential, the size of mitochondria, time of opening of mitochondrial permeability transition pore (mPTP), mitochondrial respiration rate, antioxidant activity, or nitric oxide level.

引用

页码：442 / 448

页数：7

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