Epidemiology and Genetic Characterization of Leishmania RNA Virus in Leishmania (Viannia) spp. Isolates from Cutaneous Leishmaniasis Endemic Areas in Panama

被引：0

作者：

Bonilla, Armando Assair ^{[1
]}

Pineda, Vanessa ^{[2
]}

Calzada, Jose Eduardo ^{[2
,3
]}

Saldana, Azael ^{[4
]}

Laurenti, Marcia Dalastra ^{[5
]}

Goya, Stephanie ^{[6
]}

Abrego, Leyda ^{[7
,8
]}

Gonzalez, Kadir ^{[2
,9
]}

机构：

[1] Univ Panama, Fac Ciencias Nat Exactas & Tecnol, Programa Maestria Ciencias Parasitol, Panama City, Panama

[2] Inst Conmemorat Gorgas Estudios Salud, Dept Invest Parasitol, Panama City 02593, Panama

[3] Univ Panama, Fac Med Vet, Panama City, Panama

[4] Univ Panama, Fac Med, Ctr Invest & Diagnost Enfermedades Parasitarias CI, Panama City, Panama

[5] Univ Sao Paulo, Fac Med, Lab Patol Molestias Infecciosas, BR-05508270 Sao Paulo, SP, Brazil

[6] Univ Washington, Dept Lab Med & Pathol, Seattle, WA 98195 USA

[7] Inst Conmemorat Gorgas Estudios Salud, Dept Invest Virol & Biotecnol, Panama City 02593, Panama

[8] Univ Panama, Fac Ciencias Nat Exactas & Tecnol, Dept Microbiol & Parasitol, Panama City, Panama

[9] Univ Panama, Fac Med, Dept Microbiol Humana, Panama City, Panama

来源：

MICROORGANISMS | 2024年 / 12卷 / 07期

关键词：

LRV; Leishmaniavirus; Leishmania Viannia; leishmaniasis; phylogenetic; sequencing; Panama; AMERICAN TEGUMENTARY LEISHMANIASIS; IDENTIFICATION; SEQUENCE; MODEL; GUYANENSIS; ALIGNMENT; PARASITES; SEVERITY; CHOICE; LRV1;

D O I：

10.3390/microorganisms12071317

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Leishmania (Viannia) spp. can harbor a double-stranded RNA virus known as Leishmania RNA virus 1 (LRV-1), whose presence has been reported in nine countries across the Americas and seven Leishmania species. Here, we studied 100 Leishmania (Viannia) isolates from patients with cutaneous leishmaniasis collected from different endemic areas in Panama from 2016 to 2022. We identified L. (V.) panamensis, L. (V.) guyanensis, L. (V.) braziliensis/guyanensis hybrid, and L. (V.) panamensis sp.1. (genetic variant). LRV-1 was detected by RT-PCR in 9% of L. (Viannia) isolates (eight cases in L. (V.) panamensis, and one in L. (V.) guyanensis). Phylogenetic analysis based on sequencing data classified all LRV-1 isolates within genotype A, suggesting that LRV phylogenetic proximity is closely aligned with geographical distribution or to the phylogenetic proximity of the Leishmania host in the case of the L. (V.) panamensis and L. (V.) guyanensis in Panama.

引用

页数：11

共 50 条

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