Gastric Ulcer From Prolonged Oral Iron Therapy: A Case Report and Literature Review

Iron deficiency is a leading cause of anemia worldwide and is commonly treated with oral iron supplements, which are known for their GI side effects. We present a case of a 66-year-old woman with a history of GI bleeding and multiple comorbidities who developed a gastric ulcer after prolonged oral iron therapy. Although GI side effects are frequent with iron supplements, ulceration is rare, with only a few documented cases. Endoscopic and histopathological evaluations identified iron deposition in the ulcer bed, confirming the diagnosis. Discontinuing the oral iron led to the resolution of symptoms. This case underscores the importance of recognizing and managing iron-induced gastric ulcers to ensure safe and effective treatment of iron deficiency.