Sensitisation to the acrylate co-polymers glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®) is rare

被引：0

作者：

Soriano, Livia F. ^{[1
]}

Chowdhury, M. M. U. ^{[2
]}

Cousen, Philippa ^{[3
]}

Dawe, Simon ^{[4
]}

Ghaffar, Sharizan A. ^{[5
]}

Haworth, Adam ^{[6
]}

Holden, Catherine R. ^{[7
]}

Hollywood, Aoife ^{[8
]}

Johnston, Graham A. ^{[9
]}

Kirk, Stephen ^{[10
]}

Mughal, Avad A. ^{[11
]}

Orton, David I. ^{[12
]}

Parker, Robin ^{[13
]}

Rajeev, Asha ^{[14
]}

Scharrer, Krisztina ^{[15
]}

Sinha, Aparna ^{[16
]}

Stone, Natalie M. ^{[17
]}

Thompson, Donna ^{[18
]}

Wakelin, Sarah ^{[12
,19
]}

Whitehouse, Heather ^{[20
]}

Wootton, Catriona ^{[21
]}

Buckley, Deirdre A. ^{[22
]}

机构：

[1] Univ Hosp Southampton NHS Trust, Southampton, England

[2] Univ Hosp Wales, Cardiff, Wales

[3] South Tees Hosp NHS Fdn Trust, Middlesbrough, England

[4] West Herts NHS Trust, Harpenden, England

[5] Ninewells Hosp & Med Sch, Dundee, Scotland

[6] St Marys Hosp, Portsmouth, England

[7] Sheffield Teaching Hosp Fdn Trust, Sheffield, England

[8] South Infirm Victoria Univ Hosp, Cork, Ireland

[9] Univ Hosp Leicester NHS Trust, Leicester, England

[10] SK CRS Ltd, Nottingham, England

[11] Swansea Bay Univ Hlth Board, Swansea, Wales

[12] OneWelbeck Skin Hlth & Allergy, London, England

[13] THG Labs Acheson, Frome, Wilts, England

[14] East Kent Hosp Univ NHS Fdn Trust, Thanet, Kent, England

[15] United Lincolnshire Hosp Trust, Lincoln, Lincs, England

[16] Univ Hosp Bristol & Weston NHS Fdn Trust, Bristol, England

[17] Aneurin Bevan Univ Healthboard, Newport, Wales

[18] Sandwell & West Birmingham Hosp NHS Trust, Birmingham, England

[19] Imperial Coll Healthcare NHS Trust, London, England

[20] Leeds Teaching Hosp NHS Trust, Leeds, England

[21] Oxford Univ Hosp NHS Trust, Oxford, England

[22] Sulis Hosp, Bath, England

来源：

CONTACT DERMATITIS | 2024年 / 91卷 / 06期

关键词：

acrylate co-polymers; acrylates; allergic; contact dermatitis; ALLERGIC CONTACT-DERMATITIS; SAFETY ASSESSMENT; PRESERVATIVES; METHACRYLATE;

D O I：

10.1111/cod.14679

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Acrylate polymers and cross-polymers (ACPs) are frequently used cosmetic ingredients. The British Society for Cutaneous Allergy (BSCA) and the UK Cosmetic, Toiletry and Perfumery Association (CTPA) collaborated to investigate the allergenic potential of three commonly-used ACPs. Objectives: The objective of this study is to determine the prevalence of allergic contact dermatitis (ACD) to three ACPs: glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate, and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol (R)). Materials and Methods: The BSCA prospectively audited data collected from 20 centres in the UK and Ireland between 1st September 2021 and 1st September 2022. Patients with suspected ACD to (meth)acrylates, with facial dermatitis, or consecutive patients, were patch tested to glyceryl acrylate/acrylic acid co-polymer 10% aqueous (aq.) sodium polyacrylate 2% aq., and to acrylates/C10-30 alkyl acrylate cross-polymer 2% aq. (Carbopol (R)). The frequencies of positive, irritant, and doubtful reactions were recorded. Results: In total, 1302 patients were patch tested. To glyceryl acrylate/acrylic acid co-polymer, there was one doubtful reaction in a patient allergic to multiple (meth)acrylates, and one irritant. To sodium polyacrylate, there were four irritant reactions, one doubtful, and one positive reaction; in all cases, relevance was unknown and there was no demonstrable (meth)acrylate allergy. There were no reactions to Carbopol (R). Conclusions: Sensitisation to these concentrations of the three tested ACPs is rare. Elicitation of dermatitis in (meth)acrylate-sensitised patients by exposure to these three ACPs appears unlikely.

引用

页码：491 / 496

页数：6

共 2 条

[1] EVALUATION OF ACRYLATES/C10-30 ALKYL ACRYLATE CROSS POLYMER MIXTURE EFFECTIVENESS ON O/W TYPE EMULSION FORMULATION
Kizeviciene, Edita
Jonaitiene, Laimute
Peciura, Rimantas
ACTA POLONIAE PHARMACEUTICA, 2017, 74 (03): : 937 - 943
[2] SYNTHESIS OF N-PARA-TOLYLMALEIMIDE METHYL ACRYLATE CO-POLYMERS AND EFFECT OF CO-POLYMER COMPOSITION ON HUGGINS CONSTANT
PATEL, MR
PATEL, JD
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1983, 22 (02): : 163 - 165

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